Infliximab for peripheral ulcerative keratitis treatment
Resumen: Biologic agents such as anti-TNFa have been employed in treatment paradigms for ocular inflammation. Peripheral corneal ulceration (PUK) is a devastating disorder consisting of a crescent-shaped area of destructive inflammation at the margin of the corneal stroma. It is associated with an epithelial defect, the presence of stromal inflammatory cells, and progressive stromal degradation and thinning, leading to ocular perforation and devastating visual loss. Macroulcerative PUK is usually a local manifestation of a systemic vasculitis. In many cases, the disease may be resistant to high doses of systemic corticosteroids and immunosuppressants. Chimeric anti-TNFa has been employed when all other treatments have failed. Isolated cases and short series of cases have been reported. This paper summarizes the available reports on the use, efficacy, and safety of infliximab in the treatment of PUK.
Idioma: Inglés
DOI: 10.1097/MD.0000000000000176
Año: 2014
Publicado en: Medicine (Baltimore) 93, 26 (2014), e176 [4 pp]
ISSN: 0025-7974

Factor impacto JCR: 5.723 (2014)
Categ. JCR: MEDICINE, GENERAL & INTERNAL rank: 15 / 154 = 0.097 (2014) - Q1 - T1
Factor impacto SCIMAGO:

Tipo y forma: Article (Published version)
Área (Departamento): Oftalmología (Departamento de Cirugía, Ginecología y Obstetricia)

Creative Commons You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

Exportado de SIDERAL (2017-11-16-13:55:02)

Este artículo se encuentra en las siguientes colecciones:
Articles > Artículos por área > Oftalmología

 Record created 2017-11-16, last modified 2017-11-17

Versión publicada:
Rate this document:

Rate this document:
(Not yet reviewed)