One-pot synthesis of unsymmetrical squaramides
Resumen: The results concerning the first one-pot synthesis of unsymmetrical squaramides are reported. This straightforward procedure allows appealing and commonly used squaramide derivatives to be obtained with very good results. The methodology developed in this work saves energy, eliminates the purification steps for intermediate products, reduces costs and leads to better yields compared to those obtained through the traditional “stop-and-go” approach. Moreover, we have proved the efficiency of our process with the synthesis of three biologically active structures, improving the results of the previously reported stepwise syntheses. Interestingly, this simple and cheap method could attract the interest of pharmaceutical and chemical companies aiming to produce these active compounds on a large scale.
Idioma: Inglés
DOI: 10.1039/c5ra05383h
Año: 2015
Publicado en: RSC Advances 5 (2015), [15 pp.]
ISSN: 2046-2069

Factor impacto JCR: 3.289 (2015)
Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 48 / 163 = 0.294 (2015) - Q2 - T1
Factor impacto SCIMAGO: 0.947 - Chemistry (miscellaneous) (Q1) - Chemical Engineering (miscellaneous) (Q1)

Tipo y forma: Article (PostPrint)
Área (Departamento): Área Química Orgánica (Dpto. Química Orgánica)

Rights Reserved All rights reserved by journal editor

Exportado de SIDERAL (2021-01-21-10:53:54)

Este artículo se encuentra en las siguientes colecciones:

 Record created 2017-11-28, last modified 2021-01-21

Rate this document:

Rate this document:
(Not yet reviewed)