An expedient synthesis of resveratrol through a highly recoverable palladium catalyst

Martínez, Alejandro V. ; García, José I. ; Mayoral, José A. (Universidad de Zaragoza)

Resumen: A straightforward two-step synthesis of resveratrol is described, with total isolated yields in the range of 75–80%. The key synthetic step, a Heck–Mizoroki C[sbnd]C cross-coupling reaction, is efficiently promoted by a heterogeneous catalyst consisting of palladium nanoparticles supported on synthetic clay. This solid catalyst is quite handy and displays high stability and robustness under reaction conditions. The catalyst can be easily recovered and reused at least 10 times, which improves the overall catalytic efficiency of the system. Moreover, the use of solvents is limited, and the reaction procedure allows a facile separation and purification of the desired product, free from the concomitant ionic by-product and from palladium contamination.

Idioma: Inglés

DOI: 10.1016/j.tet.2016.08.074

Año: 2017

Publicado en: TETRAHEDRON 73, 38 (2017), 5581-5584
ISSN: 0040-4020

Factor impacto JCR: 2.377 (2017)

Categ. JCR: CHEMISTRY, ORGANIC rank: 23 / 57 = 0.404 (2017) - Q2 - T2

Factor impacto SCIMAGO: 0.8 - Biochemistry (Q2) - Organic Chemistry (Q2) - Drug Discovery (Q2)

Financiación: info:eu-repo/grantAgreement/ES/DGA/E11
Financiación: info:eu-repo/grantAgreement/ES/MINECO/CTQ2014-52367-R

Tipo y forma: Article (PostPrint)

Área (Departamento): Área Química Orgánica (Dpto. Química Orgánica)