Inflammation in metabolically healthy and metabolically abnormal adolescents: The HELENA study

González-Gil, E.M. (Universidad de Zaragoza) ; Cadenas-Sanchez, C. ; Santabárbara, J. (Universidad de Zaragoza) ; Bueno-Lozano, G. (Universidad de Zaragoza) ; Iglesia, I. ; González-Gross, M. ; Molnar, D. ; Gottrand, F. ; De Henauw, S. ; Kafatos, A. ; Widhalm, K. ; Manios, Y. ; Siani, A. ; Amaro-Gahete, F. ; Rupérez A.I. (Universidad de Zaragoza) ; Cañada, D. ; Censi, L. ; Kersting, M. ; Dallongeville, J. ; Marcos, A. ; Ortega, F.B. ; Moreno, L.A. (Universidad de Zaragoza) ; Moreno, L.A. ; Gottrand, F. ; De Henauw, S. ; González-Gross, M. ; Gilbert, C. ; Kafatos, A. ; Libersa, C. ; Castelló, S. ; Kersting, M. ; Sjöstrom, M. ; Molnár, D. ; Dallongeville, J. ; Hall, G. ; Maes, L. ; Scalfi, L. ; Meléndez, P. ; Fleta, J. ; Casajús, J.A. ; Rodríguez, G. ; Tomás, C. ; Mesana, M.I. ; Vicente-Rodríguez, G. ; Villarroya, A. ; Gil, C.M. ; Ara, I. ; Alvira, J.F. ; Bueno, G. ; Lázaro, A. ; Bueno, O. ; León, J.F. ; Garagorri, J.M. ; Bueno, M. ; Labayen, I. ; Iglesia, I. ; Bel Serrat, S. ; Gracia Marco, L.A. ; Mouratidou, T. ; Santaliestra-Pasías, A. ; González-Gil, E.M. ; De Miguel-Etayo, P. ; Julián Almárcegui, C. ; Miguel-Berges, M. ; Iguacel, I. ; Marcos, A. ; Wärnberg, J. ; Nova, E. ; Gómez, S. ; Díaz, L.E. ; Romeo, J. ; Veses, A. ; Zapatera, B. ; Pozo, T. ; Martínez, D. ; Beghin, L. ; Gottrand, F. ; Iliescu, C. ; Von Berlepsch, J. ; Sichert-Hellert, W. ; Koeppen, E. ; Molnar, D. ; Erhardt, E. ; Csernus, K. ; Török, K. ; Bokor, S. ; Angster ; Nagy, E. ; Kovács, O. ; Répasi, J. ; Codrington, C. ; Plada, M. ; Papadaki, A. ; Sarri, K. ; Viskadourou, A. ; Hatzis, C. ; Kiriakakis, M. ; Tsibinos, G. ; Vardavas, C. ; Sbokos, M. ; Protoyeraki, E. ; Fasoulaki, M. ; Stehle, P. ; Pietrzik, K. ; Breidenassel, C. ; Spinneker, A. ; Al-Tahan, J. ; Segoviano, M. ; Berchtold, A. ; Bierschbach, C. ; Blatzheim, E. ; Schuch, A. ; Pickert, P. ; Castillo, M.J. ; Gutiérrez, Á. ; Ortega, F.B. ; Ruiz, J.R. ; Artero, E.G. ; España, V. ; Jiménez-Pavón, D. ; Chillón, P. ; Sánchez-Muñoz, C. ; Cuenca, M. ; Arcella, D. ; Azzini, E. ; Barrison, E. ; Bevilacqua, N. ; Buonocore, P. ; Catasta, G. ; Censi, L. ; Ciarapica, D. ; D''Acapito, P. ; Ferrari, M. ; Galfo, M. ; Le Donne, C. ; Leclercq, C. ; Maiani, G. ; Mauro, B. ; Mistura, L. ; Pasquali, A. ; Piccinelli, R. ; Polito, A. ; Roccaldo, R. ; Spada, R. ; Sette, S. ; Zaccaria, M. ; Vitaglione, P. ; Montagnese, C. ; De Bourdeaudhuij, I. ; De Vriendt, T. ; Matthys, C. ; Vereecken, C. ; de Maeyer, M. ; Ottevaere, C. ; Huybrechts, I. ; Widhalm, K. ; Phillipp, K. ; Dietrich, S. ; Widhalm, K. ; Phillipp, K. ; Dietrich, S. ; Manios, Y. ; Grammatikaki, E. ; Bouloubasi, Z. ; Cook, T.L. ; Eleutheriou, S. ; Consta, O. ; Moschonis, G. ; Katsaroli, I. ; Kraniou, G. ; Papoutsou, S. ; Keke, D. ; Petraki, I. ; Bellou, E. ; Tanagra, S. ; Kallianoti, K. ; Argyropoulou, D. ; Tsikrika, S. ; Karaiskos, C. ; Meirhaeghe, A. ; Meirhaeghe, A. ; Ortega, F.B. ; Hagströmer, M. ; Wennlöf, A.H. ; Hallström, L. ; Patterson, E. ; Kwak, L. ; Rizzo, N. ; Sánchez-Molero, J. ; Picó, E. ; Navarro, M. ; Viadel, B. ; Carreres, J.E. ; Merino, G. ; Sanjuán, R. ; Lorente, M. ; Sánchez, M.J. ; Thomas, S. ; Allchurch, E. ; Burgess, P. ; Astrom, A. ; Sverkén, A. ; Broberg, A. ; Masson, A. ; Lehoux, C. ; Brabant, P. ; Pate, P. ; Fontaine, L. ; Sebok, A. ; Kuti, T. ; Hegyi, A. ; Maldonado, C.

Resumen: Background and aims Inflammation may influence the cardio-metabolic profile which relates with the risk of chronic diseases. This study aimed to assess the inflammatory status by metabolic health (MH)/body mass index (BMI) category and to assess how inflammatory markers can predict the cardio-metabolic profile in European adolescents, considering BMI. Methods and results A total of 659 adolescents (295 boys) from a cross-sectional European study were included. Adolescents were classified by metabolic health based on age- and sex-specific cut-off points for glucose, blood pressure, triglycerides, high density cholesterol and BMI. C-reactive protein (CRP), tumor necrosis factor alpha (TNF-a), interleukin (IL-6), complement factors (C3, C4) and cell adhesion molecules were assessed. Results Metabolically abnormal (MA) adolescents had higher values of C3 (p < 0.001) and C4 (p = 0.032) compared to those metabolically healthy (MHy). C3 concentrations significantly increased with the deterioration of the metabolic health and BMI (p < 0.001). Adolescents with higher values of CRP had higher probability of being in the overweight/obese-MH group than those allocated in other categories. Finally, high C3 and C4 concentrations increased the probability of having an unfavorable metabolic/BMI status. Conclusions Metabolic/BMI status and inflammatory biomarkers are associated, being the CRP, C3 and C4 the most related inflammatory markers with this condition. C3 and C4 were associated with the cardio-metabolic health consistently.

Idioma: Inglés

DOI: 10.1016/j.numecd.2017.10.004

Año: 2018

Publicado en: Nutrition, Metabolism and Cardiovascular Diseases 28, 1 (2018), 77-83
ISSN: 0939-4753

Factor impacto JCR: 3.34 (2018)

Categ. JCR: CARDIAC & CARDIOVASCULAR SYSTEMS rank: 50 / 135 = 0.37 (2018) - Q2 - T2
Categ. JCR: NUTRITION & DIETETICS rank: 33 / 85 = 0.388 (2018) - Q2 - T2
Categ. JCR: ENDOCRINOLOGY & METABOLISM rank: 59 / 145 = 0.407 (2018) - Q2 - T2

Factor impacto SCIMAGO: 1.318 - Endocrinology, Diabetes and Metabolism (Q1) - Nutrition and Dietetics (Q1) - Medicine (miscellaneous) (Q1) - Cardiology and Cardiovascular Medicine (Q1)

Financiación: info:eu-repo/grantAgreement/EUR/FP6/FOOD-CT-2005-007034
Financiación: info:eu-repo/grantAgreement/ES/MINECO/BES-2014-068829
Financiación: info:eu-repo/grantAgreement/ES/MINECO/FJCI-2014-19795
Financiación: info:eu-repo/grantAgreement/ES/MINECO/JCI-2010-07055
Financiación: info:eu-repo/grantAgreement/ES/MINECO/RYC-2011-09011

Tipo y forma: Article (PostPrint)

Área (Departamento): Área Enfermería (Dpto. Fisiatría y Enfermería)
Área (Departamento): Área Medic.Prevent.Salud Públ. (Dpto. Microb.Med.Pr.,Sal.Públ.)
Área (Departamento): Área Pediatría (Dpto. Pediatría Radiol.Med.Fís)