High-Precision Photothermal Ablation Using Biocompatible Palladium Nanoparticles and Laser Scanning Microscopy

Rubio-Ruiz, B. ; Pérez-López, A.M. ; Bray, T.L. ; Lee, M. ; Serrels, A. ; Prieto, M. ; Arruebo, M. (Universidad de Zaragoza) ; Carragher, N.O. ; Sebastián, V. (Universidad de Zaragoza) ; Unciti-Broceta, A.

Resumen: Herein, we report a straightforward method for the scalable preparation of Pd nanoparticles (Pd-NPs) with reduced inherent cytotoxicity and high photothermal conversion capacity. These Pd-NPs are rapidly taken up by cells and able to kill labeled cancer cells upon short exposure to near-infrared (NIR) light. Following cell treatment with Pd-NPs, ablated areas were patterned with high precision by laser scanning microscopy, allowing one to perform cell migration assays with unprecedented accuracy. Using coherent Raman microscopy, cells containing Pd-NPs were simultaneously ablated and imaged. This novel methodology was combined with intravital imaging to mediate microablation of cancerous tissue in tumor xenografts in mice.

Idioma: Inglés

DOI: 10.1021/acsami.7b17282

Año: 2018

Publicado en: ACS Applied Materials & Interfaces 10, 4 (2018), 3341-3348
ISSN: 1944-8244

Factor impacto JCR: 8.456 (2018)

Categ. JCR: NANOSCIENCE & NANOTECHNOLOGY rank: 16 / 94 = 0.17 (2018) - Q1 - T1
Categ. JCR: MATERIALS SCIENCE, MULTIDISCIPLINARY rank: 27 / 293 = 0.092 (2018) - Q1 - T1

Factor impacto SCIMAGO: 2.596 - Materials Science (miscellaneous) (Q1) - Nanoscience and Nanotechnology (Q1) - Medicine (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/EC/FP7/614715/EU/A Photo-triggered On-demand Drug Delivery System for Chronic Pain/NANOHEDONISM
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/CIBER-BBN
Financiación: info:eu-repo/grantAgreement/ES/UZ/JIUZ-2016-TEC-13

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Ingeniería Química (Dpto. Ing.Quím.Tecnol.Med.Amb.)