Comparison of ECG T-wave Duration and Morphology Restitution Markers for Sudden Cardiac Death Prediction in Chronic Heart Failure

Ramírez (Universidad de Zaragoza) ; Julia ; Orini (Universidad de Zaragoza) ; Michele (Universidad de Zaragoza) ; Pueyo ; Esther ; Laguna ; Pablo

Resumen: An index of T-wave morphology restitution, TMR, has previously shown to be a sudden cardiac death (SCD) predictor in a population of chronic heart failure (CHF) patients. The aim of this study is to compare the predictive value of TMR, T-wave width restitution (TWR), Tpeak-to-end (Tpe) morphology restitution (TpeMR) and Tpe duration restitution (T peR) indices in the same CHF population. Holter ECG recordings from 651 CHF patients of the MUSIC study, including SCD victims and survivors, were analyzed. TMR was significantly correlated with T W R (¿=0.66), T peM R (¿=0.70) and T peR (¿=0.42). SCD victims showed significantly higher values of TMR, TWR and TpeMR than the rest of patients, with T M R being the index most strongly associated with SCD (p=0.002, p=0.006 and p=0.011, respectively). T peR values were only borderline significantly higher in SCD victims (p=0.061). Univariate Cox analysis showed that T M R was the restitution index with the strongest predictive value (hazard ratio (HR) of 1.466, p<0.001), followed by TWR (HR of 1.295, p=0.005), TpeR (HR of 1.297, p=0.004) and T peM R (HR of 1.164, p=0.020). In conclusion, considering the predictive value of the four Twave restitution indices, TMR is the preferred index for SCD risk stratification, followed by TpeMR. However, the marker TWR could also be used for SCD prediction when computational efficiency is an issue.

Idioma: Inglés

DOI: 10.22489/CinC.2017.224-267

Año: 2017

Publicado en: Computing in Cardiology 44 (2017), [4 pp]
ISSN: 2325-8861

Financiación: info:eu-repo/grantAgreement/EC/H2020/638284/EU/Is your heart aging well? A systems biology approach to characterize cardiac aging from the cell to the body surface/MODELAGE
Financiación: info:eu-repo/grantAgreement/ES/MINECO/DPI2016-75458-R
Financiación: info:eu-repo/grantAgreement/ES/MINECO/TIN2013-41998-R

Tipo y forma: Article (PostPrint)

Área (Departamento): Área Teoría Señal y Comunicac. (Dpto. Ingeniería Electrón.Com.)