Gold-Triggered Uncaging Chemistry in Living Systems

Pérez-López, A.M. ; Rubio-Ruiz, B. ; Sebastián, V. (Universidad de Zaragoza) ; Hamilton, L. ; Adam, C. ; Bray, T.L. ; Irusta, S. (Universidad de Zaragoza) ; Brennan, P.M. ; Lloyd-Jones, G.C. ; Sieger, D. ; Santamaría, J. (Universidad de Zaragoza) ; Unciti-Broceta, A.

Resumen: Recent advances in bioorthogonal catalysis are increasing the capacity of researchers to manipulate the fate of molecules in complex biological systems. A bioorthogonal uncaging strategy is presented, which is triggered by heterogeneous gold catalysis and facilitates the activation of a structurally diverse range of therapeutics in cancer cell culture. Furthermore, this solid-supported catalytic system enabled locally controlled release of a fluorescent dye into the brain of a zebrafish for the first time, offering a novel way to modulate the activity of bioorthogonal reagents in the most fragile and complex organs.

Idioma: Inglés

DOI: 10.1002/anie.201705609

Año: 2017

Publicado en: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 56, 41 (2017), 12548-12552
ISSN: 1433-7851

Factor impacto JCR: 12.102 (2017)

Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 14 / 171 = 0.082 (2017) - Q1 - T1

Factor impacto SCIMAGO: 6.155 - Chemistry (miscellaneous) (Q1) - Catalysis (Q1)

Financiación: info:eu-repo/grantAgreement/EC/FP7/340163/EU/New Catalytic Reactions and Exchange Pathways: Delivering Versatile and Reliable Arylation/ARYLATOR
Financiación: info:eu-repo/grantAgreement/ES/UZ/JIUZ-2016-TEC-13

Tipo y forma: Congress (Published version)

Área (Departamento): Área Ingeniería Química (Dpto. Ing.Quím.Tecnol.Med.Amb.)