Altered gene expression in human placenta after suspected preterm labour

Oros, D. ; Strunk, M. ; Breton, P. ; Paules, C. ; Benito, R. (Universidad de Zaragoza) ; Moreno, E. ; Garcés, M. ; Godino, J. ; Schoorlemmer, J. (Universidad de Zaragoza)

Resumen: Introduction Suspected preterm labour occurs in around 9% of pregnancies. However, almost two-thirds of women admitted for threatened preterm labour ultimately deliver at term and are considered risk-free for fetal development. Methods We examined placental and umbilical cord blood samples from preterm or term deliveries after threatened preterm labour as well as term deliveries without threatened preterm labour. We quantitatively analysed the mRNA expression of inflammatory markers (IL6, IFN?, and TNFa) and modulators of angiogenesis (FGF2, PGF, VEGFA, VEGFB, and VEGFR1). Results A total of 132 deliveries were analysed. Preterm delivery and term delivery after suspected preterm labour groups showed similar increases in TNFa expression compared with the term delivery control group in umbilical cord blood samples. Placental samples from preterm and term deliveries after suspected preterm labour exhibited significantly increased expression of TNFa and IL6 and decreased expression of IFN?. Suspected preterm labour was also associated with altered expression of angiogenic factors, although not all differences reached statistical significance. Discussion We found gene expression patterns indicative of inflammation in human placentas after suspected preterm labour regardless of whether the deliveries occurred preterm or at term. Similarly, a trend towards altered expression of angiogeneic factors was not limited to preterm birth. These findings suggest that the biological mechanisms underlying threatened preterm labour affect pregnancies independently of gestational age at birth.

Idioma: Inglés

DOI: 10.1016/j.placenta.2017.04.025

Año: 2017

Publicado en: PLACENTA 55 (2017), 21-28
ISSN: 0143-4004

Factor impacto JCR: 2.434 (2017)

Categ. JCR: DEVELOPMENTAL BIOLOGY rank: 21 / 42 = 0.5 (2017) - Q2 - T2
Categ. JCR: OBSTETRICS & GYNECOLOGY rank: 29 / 81 = 0.358 (2017) - Q2 - T2
Categ. JCR: REPRODUCTIVE BIOLOGY rank: 16 / 29 = 0.552 (2017) - Q3 - T2

Factor impacto SCIMAGO: 1.223 - Obstetrics and Gynecology (Q1) - Reproductive Medicine (Q1) - Developmental Biology (Q2)

Financiación: info:eu-repo/grantAgreement/ES/DGA/B87-2014
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI10-301

Tipo y forma: Artículo (PostPrint)

Área (Departamento): Área Microbiología (Dpto. Microb.Med.Pr.,Sal.Públ.)
Área (Departamento): Área Anatom.Anatom.Patológ.Com (Dpto. Anatom.,Embri.Genét.Ani.)