000070176 001__ 70176 000070176 005__ 20190709135452.0 000070176 0247_ $$2doi$$a10.1016/j.placenta.2017.04.025 000070176 0248_ $$2sideral$$a98961 000070176 037__ $$aART-2017-98961 000070176 041__ $$aeng 000070176 100__ $$0(orcid)0000-0002-0670-5541$$aOros, D. 000070176 245__ $$aAltered gene expression in human placenta after suspected preterm labour 000070176 260__ $$c2017 000070176 5060_ $$aAccess copy available to the general public$$fUnrestricted 000070176 5203_ $$aIntroduction Suspected preterm labour occurs in around 9% of pregnancies. However, almost two-thirds of women admitted for threatened preterm labour ultimately deliver at term and are considered risk-free for fetal development. Methods We examined placental and umbilical cord blood samples from preterm or term deliveries after threatened preterm labour as well as term deliveries without threatened preterm labour. We quantitatively analysed the mRNA expression of inflammatory markers (IL6, IFN?, and TNFa) and modulators of angiogenesis (FGF2, PGF, VEGFA, VEGFB, and VEGFR1). Results A total of 132 deliveries were analysed. Preterm delivery and term delivery after suspected preterm labour groups showed similar increases in TNFa expression compared with the term delivery control group in umbilical cord blood samples. Placental samples from preterm and term deliveries after suspected preterm labour exhibited significantly increased expression of TNFa and IL6 and decreased expression of IFN?. Suspected preterm labour was also associated with altered expression of angiogenic factors, although not all differences reached statistical significance. Discussion We found gene expression patterns indicative of inflammation in human placentas after suspected preterm labour regardless of whether the deliveries occurred preterm or at term. Similarly, a trend towards altered expression of angiogeneic factors was not limited to preterm birth. These findings suggest that the biological mechanisms underlying threatened preterm labour affect pregnancies independently of gestational age at birth. 000070176 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B87-2014$$9info:eu-repo/grantAgreement/ES/ISCIII/PI10-301 000070176 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/ 000070176 590__ $$a2.434$$b2017 000070176 591__ $$aDEVELOPMENTAL BIOLOGY$$b21 / 42 = 0.5$$c2017$$dQ2$$eT2 000070176 591__ $$aOBSTETRICS & GYNECOLOGY$$b29 / 81 = 0.358$$c2017$$dQ2$$eT2 000070176 591__ $$aREPRODUCTIVE BIOLOGY$$b16 / 29 = 0.552$$c2017$$dQ3$$eT2 000070176 592__ $$a1.223$$b2017 000070176 593__ $$aObstetrics and Gynecology$$c2017$$dQ1 000070176 593__ $$aReproductive Medicine$$c2017$$dQ1 000070176 593__ $$aDevelopmental Biology$$c2017$$dQ2 000070176 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion 000070176 700__ $$aStrunk, M. 000070176 700__ $$aBreton, P. 000070176 700__ $$aPaules, C. 000070176 700__ $$0(orcid)0000-0001-5134-1006$$aBenito, R.$$uUniversidad de Zaragoza 000070176 700__ $$aMoreno, E. 000070176 700__ $$aGarcés, M. 000070176 700__ $$aGodino, J. 000070176 700__ $$aSchoorlemmer, J.$$uUniversidad de Zaragoza 000070176 7102_ $$11008$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Med.Pr.,Sal.Públ.$$cÁrea Microbiología 000070176 7102_ $$11001$$2025$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Anatom.Anatom.Patológ.Com 000070176 773__ $$g55 (2017), 21-28$$pPlacenta$$tPLACENTA$$x0143-4004 000070176 8564_ $$s1747212$$uhttps://zaguan.unizar.es/record/70176/files/texto_completo.pdf$$yPostprint 000070176 8564_ $$s56863$$uhttps://zaguan.unizar.es/record/70176/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint 000070176 909CO $$ooai:zaguan.unizar.es:70176$$particulos$$pdriver 000070176 951__ $$a2019-07-09-11:41:40 000070176 980__ $$aARTICLE