Spasmolytic effect of Jasonia glutinosa on rodent intestine

Castro, Marta (Universidad de Zaragoza) ; Ramón Giménez, Mariano ; Les, Francisco ; Trejo, Lorena ; Plaza, Miguel Ángel (Universidad de Zaragoza) ; López, Víctor ; Murillo, María Divina ; Valero, Marta Sofia (Universidad de Zaragoza)

Resumen: Introduction: Jasonia glutinosa is an endemic plant species of the Iberian Peninsula and Southern France traditionally used in infusions as a spasmolytic; this plant is also known as "te de roca" (rock tea) but there is no scientific evidence about the effects of this plant. Aim: To evaluate the spasmolytic effect of rock tea. Methods: We have studied the in vitro effect of a rock tea extract on rat duodenum spontaneous contractions and the in vivo effect on mice gastrointestinal transit. Results: Rock tea extract reduced the spontaneous contractions of rat duodenal smooth muscle, inhibited KCl-induced contractions and blocked the contractions invoked by both extracellular Ca2+ and the agonist of L-type calcium channels Bay K8644. This inhibitory effect was similar to the one observed after the addition of the antagonist of L-type calcium channels verapamil. Rock tea did not modify gastrointestinal transit in healthy mice. However, after the treatment with dextran sulfate sodium, an inducer of colitis, rock tea extract reverted the increase in the gastrointestinal transit associated with this treatment. Conclusion: Rock tea extract relaxed duodenal smooth muscle via L-type calcium channels and normalized gastrointestinal transit in a model of colitis. These results may validate the traditional use of Jasonia glutinosa in patients with gastrointestinal alterations. Thus, rock tea may be used as a spasmolytic agent to treat gastrointestinal disorders.

Idioma: Inglés

DOI: 10.17235/reed.2016.4327/2016

Año: 2016

Publicado en: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS 108, 12 (2016), 785-789
ISSN: 1130-0108

Factor impacto JCR: 1.401 (2016)

Categ. JCR: GASTROENTEROLOGY & HEPATOLOGY rank: 69 / 79 = 0.873 (2016) - Q4 - T3

Factor impacto SCIMAGO: 0.445 - Medicine (miscellaneous) (Q2) - Gastroenterology (Q3)

Financiación: info:eu-repo/grantAgreement/ES/DGA/B61
Financiación: info:eu-repo/grantAgreement/ES/DGA/E02
Financiación: info:eu-repo/grantAgreement/ES/DGA-FEDER/Construyendo Europa desde Aragón

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Fisiología (Dpto. Farmacología y Fisiolog.)