000070641 001__ 70641 000070641 005__ 20201009175923.0 000070641 0247_ $$2doi$$a10.17235/reed.2016.4327/2016 000070641 0248_ $$2sideral$$a106014 000070641 037__ $$aART-2016-106014 000070641 041__ $$aeng 000070641 100__ $$0(orcid)0000-0001-8584-3979$$aCastro, Marta$$uUniversidad de Zaragoza 000070641 245__ $$aSpasmolytic effect of Jasonia glutinosa on rodent intestine 000070641 260__ $$c2016 000070641 5060_ $$aAccess copy available to the general public$$fUnrestricted 000070641 5203_ $$aIntroduction: Jasonia glutinosa is an endemic plant species of the Iberian Peninsula and Southern France traditionally used in infusions as a spasmolytic; this plant is also known as "te de roca" (rock tea) but there is no scientific evidence about the effects of this plant. Aim: To evaluate the spasmolytic effect of rock tea. Methods: We have studied the in vitro effect of a rock tea extract on rat duodenum spontaneous contractions and the in vivo effect on mice gastrointestinal transit. Results: Rock tea extract reduced the spontaneous contractions of rat duodenal smooth muscle, inhibited KCl-induced contractions and blocked the contractions invoked by both extracellular Ca2+ and the agonist of L-type calcium channels Bay K8644. This inhibitory effect was similar to the one observed after the addition of the antagonist of L-type calcium channels verapamil. Rock tea did not modify gastrointestinal transit in healthy mice. However, after the treatment with dextran sulfate sodium, an inducer of colitis, rock tea extract reverted the increase in the gastrointestinal transit associated with this treatment. Conclusion: Rock tea extract relaxed duodenal smooth muscle via L-type calcium channels and normalized gastrointestinal transit in a model of colitis. These results may validate the traditional use of Jasonia glutinosa in patients with gastrointestinal alterations. Thus, rock tea may be used as a spasmolytic agent to treat gastrointestinal disorders. 000070641 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FEDER/Construyendo Europa desde Aragón$$9info:eu-repo/grantAgreement/ES/DGA/E02$$9info:eu-repo/grantAgreement/ES/DGA/B61 000070641 540__ $$9info:eu-repo/semantics/openAccess$$aby-sa$$uhttp://creativecommons.org/licenses/by-sa/3.0/es/ 000070641 590__ $$a1.401$$b2016 000070641 591__ $$aGASTROENTEROLOGY & HEPATOLOGY$$b69 / 79 = 0.873$$c2016$$dQ4$$eT3 000070641 592__ $$a0.445$$b2016 000070641 593__ $$aMedicine (miscellaneous)$$c2016$$dQ2 000070641 593__ $$aGastroenterology$$c2016$$dQ3 000070641 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000070641 700__ $$aRamón Giménez, Mariano 000070641 700__ $$0(orcid)0000-0002-7972-7119$$aLes, Francisco 000070641 700__ $$aTrejo, Lorena 000070641 700__ $$0(orcid)0000-0002-7412-2073$$aPlaza, Miguel Ángel$$uUniversidad de Zaragoza 000070641 700__ $$aLópez, Víctor 000070641 700__ $$0(orcid)0000-0002-3917-4740$$aMurillo, María Divina 000070641 700__ $$0(orcid)0000-0002-2231-7565$$aValero, Marta Sofia$$uUniversidad de Zaragoza 000070641 7102_ $$11005$$2410$$aUniversidad de Zaragoza$$bDpto. Farmacología y Fisiolog.$$cÁrea Fisiología 000070641 773__ $$g108, 12 (2016), 785-789$$pRev. esp. enferm. dig.$$tREVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS$$x1130-0108 000070641 8564_ $$s636328$$uhttps://zaguan.unizar.es/record/70641/files/texto_completo.pdf$$yVersión publicada 000070641 8564_ $$s110741$$uhttps://zaguan.unizar.es/record/70641/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000070641 909CO $$ooai:zaguan.unizar.es:70641$$particulos$$pdriver 000070641 951__ $$a2020-10-09-17:47:10 000070641 980__ $$aARTICLE