Non-invasive ventilation in obesity hypoventilation syndrome without severe obstructive sleep apnoea
Masa, J.F. ; Corral, J. ; Caballero, C. ; Barrot, E. ; Teran-Santos, J. ; Alonso-Alvarez, M.L. ; Gomez-Garcia, T. ; Gonzalez, M. ; Lopez-Martin, S. ; De Lucas, P. ; Marin, J.M. (Universidad de Zaragoza) ; Marti, S. ; Diaz-Cambriles, T. ; Chiner, E. ; Egea, C. ; Miranda, E. ; Mokhlesi, B. ; Garcia-Ledesma, E. ; Sanchez-Quiroga, M.A. ; Ordax, E. ; Gonzalez-Mangado, N. ; Troncoso, M.F. ; Martinez-Martinez, M.A. ; Cantalejo, O. ; Ojeda, E. ; Carrizo, S.J. ; Gallego, B. ; Pallero, M. ; Ramon, M.A. ; Diaz-de-Atauri, J. ; Munoz-Mendez, J. ; Senent, C. ; Sancho-Chust, J.N. ; Ribas-Solis, F.J. ; Romero, A. ; Benitez, J.M. ; Sanchez-Gomez, J. ; Golpe, R. ; Santiago-Recuerda, A. ; Gomez, S. ; Bengoa, M.
Resumen: Background Non-invasive ventilation (NIV) is an effective form of treatment in patients with obesity hypoventilation syndrome (OHS) who have concomitant severe obstructive sleep apnoea (OSA). However, there is a paucity of evidence on the efficacy of NIV in patients with OHS without severe OSA. We performed a multicentre randomised clinical trial to determine the comparative efficacy of NIV versus lifestyle modification (control group) using daytime arterial carbon dioxide tension (PaCO2) as the main outcome measure. Methods Between May 2009 and December 2014 we sequentially screened patients with OHS without severe OSA. Participants were randomised to NIV versus lifestyle modification and were followed for 2 months. Arterial blood gas parameters, clinical symptoms, health-related quality of life assessments, polysomnography, spirometry, 6-min walk distance test, blood pressure measurements and healthcare resource utilisation were evaluated. Statistical analysis was performed using intention-to-treat analysis. Results A total of 365 patients were screened of whom 58 were excluded. Severe OSA was present in 221 and the remaining 86 patients without severe OSA were randomised. NIV led to a significantly larger improvement in PaCO2 of -6 (95% CI -7.7 to -4.2) mm Hg versus -2.8 (95% CI -4.3 to -1.3) mm Hg, (p<0.001) and serum bicarbonate of -3.4 (95% CI -4.5 to -2.3) versus -1 (95% CI -1.7 to -0.2 95% CI) mmol/L (p<0.001). PaCO2 change adjusted for NIV compliance did not further improve the inter-group statistical significance. Sleepiness, some health-related quality of life assessments and polysomnographic parameters improved significantly more with NIV than with lifestyle modification. Additionally, there was a tendency towards lower healthcare resource utilisation in the NIV group. Conclusions NIV is more effective than lifestyle modification in improving daytime PaCO2, sleepiness and polysomnographic parameters. Long-term prospective studies are necessary to determine whether NIV reduces healthcare resource utilisation, cardiovascular events and mortality.
Idioma: Inglés
DOI: 10.1136/thoraxjnl-2016-208501
Año: 2016
Publicado en: THORAX 71, 10 (2016), 899-906
ISSN: 0040-6376
Factor impacto JCR: 8.272 (2016)
Categ. JCR: RESPIRATORY SYSTEM rank: 4 / 59 = 0.068 (2016) - Q1 - T1
Factor impacto SCIMAGO: 3.275 - Pulmonary and Respiratory Medicine (Q1)
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI05-0402
Tipo y forma: Article (Published version)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes.
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Idioma: Inglés
DOI: 10.1136/thoraxjnl-2016-208501
Año: 2016
Publicado en: THORAX 71, 10 (2016), 899-906
ISSN: 0040-6376
Factor impacto JCR: 8.272 (2016)
Categ. JCR: RESPIRATORY SYSTEM rank: 4 / 59 = 0.068 (2016) - Q1 - T1
Factor impacto SCIMAGO: 3.275 - Pulmonary and Respiratory Medicine (Q1)
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI05-0402
Tipo y forma: Article (Published version)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. Exportado de SIDERAL (2020-02-21-13:49:51)
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Record created 2018-05-22, last modified 2020-02-21