Effect of clozapine on immunoglobulin M plasma levels

Lozano, R. ; Marin, R. ; Santacruz, M.J. ; Pascual, A.

Resumen: Clozapine is an atypical antipsychotic medication indicated for the treatment of patients who fail to respond to standard antipsychotic treatment. It possesses immunomodulatory properties and requires regular counts of white blood cells and absolute neutrophils. It has been reported to mediate several effects on humoral immunity, such as altering the levels of antibody-producing cytokines [Hinze-Selch et al. 1998].
Selective immunoglobulin M immunodeficiency (SIgMD) is a rare form of dysgammaglobulinaemia characterized by a selective, low level of immunoglobulin M (IgM) in conjunction with normal T cell numbers and function, and with no other identifiable immunodeficiencies. It can occur as either a primary or secondary condition and displays an estimated prevalence of 0.03%– 3%. Secondary SIgMD can be associated with malignancy, autoimmune disorders, gastrointestinal diseases and/or immunosuppressive treatments [Goldstein et al. 2006]...

Idioma: Inglés

DOI: 10.1177/2045125315591925

Año: 2016

Publicado en: THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY 6, 1 (2016), 58-60
ISSN: 2045-1253

Tipo y forma: (Published version)