Epigenetics modifications and Subclinical Atherosclerosis in Obstructive Sleep Apnea: The EPIOSA study

Marin, José M. ; Artal, Jorge ; Martin, Teresa ; Carrizo, Santiago J. ; Andrés, Marta ; Martín Burriel, Inmaculada (Universidad de Zaragoza) ; Bolea, Rosa (Universidad de Zaragoza) ; Sanz, Arianne (Universidad de Zaragoza) ; Varona, Luis (Universidad de Zaragoza) ; Godino, Javier ; Gallego, Begoña ; Garcia-Erce, José A. ; Villar, Isabel ; Gil, Victoria ; Forner, Marta ; Cubero, José P. ; Ros Mendoza, Luis H. (Universidad de Zaragoza)

Resumen: Background
Obstructive sleep apnea (OSA) is associated with increased risk for cardiovascular morbidity and mortality. Epidemiological and animal models studies generate hypotheses for innovative strategies in OSA management by interferig intermediates mechanisms associated with cardiovascular complications. We have thus initiated the Epigenetics modification in Obstructive Sleep Apnea (EPIOSA) study (ClinicalTrials.gov identifier: NCT02131610).
Methods/design
EPIOSA is a prospective cohort study aiming to recruit 350 participants of caucasian ethnicity and free of other chronic or inflammatory diseases: 300 patients with prevalent OSA and 50 non-OSA subjects. All of them will be follow-up for at least 5 years. Recruitment and study visits are performed in single University-based sleep clinic using standard operating procedures. At baseline and at each one year follow-up examination, patients are subjected to a core phenotyping protocol. This includes a standardized questionnaire and physical examination to determine incident comorbidities and health resources utilization, with a primary focus on cardiovascular events. Confirmatory outcomes information is requested from patient records and the regional Department of Health Services. Every year, OSA status will be assessed by full sleep study and blood samples will be obtained for immediate standard biochemistry, hematology, inflammatory cytokines and cytometry analysis. For biobanking, aliquots of serum, plasma, urine, mRNA and DNA are also obtained. Bilateral carotid echography will be performed to assess subclinical atherosclerosis and atherosclerosis progression. OSA patients are treated according with national guidelines.
Discussion
EPIOSA will enable the prospective evaluation of inflammatory and epigenetics mechanism involved in cardiovascular complication of treated and non-treated patients with OSA compared with non OSA subjects.

Idioma: Inglés

DOI: 10.1186/1471-2466-14-114

Año: 2014

Publicado en: BMC pulmonary medicine 14, 114 (2014), 8
ISSN: 1471-2466

Factor impacto JCR: 2.404 (2014)

Categ. JCR: RESPIRATORY SYSTEM rank: 31 / 57 = 0.544 (2014) - Q3 - T2

Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI12-01275

Tipo y forma: Article (Published version)

Área (Departamento): Área Radiol. y Medicina Física (Dpto. Pediatría Radiol.Med.Fís)
Área (Departamento): Área Genética (Dpto. Anatom.,Embri.Genét.Ani.)
Área (Departamento): Área Sanidad Animal (Dpto. Patología Animal)