Effective in Vitro Photokilling by Cell-Adhesive Gold Nanorods

Artiga, A. ; Garcia-Embid, S. ; De Matteis, L. ; Mitchell, S.G. (Universidad de Zaragoza) ; de la Fuente, J.M. (Universidad de Zaragoza)

Resumen: Upon excitation of their localized surface plasmon resonance (LSPR) band, gold nanorods (AuNRs) show a characteristic light-to-heat transduction, a useful and versatile property for a range of biomedical applications such as photothermal therapy, drug delivery, optoacoustic imaging and biosensing, among others. Nanoparticle (NP)-mediated photothermal therapy (PTT) rests on the ability of nanomaterials to convert light energy into heat and can currently be considered as a promising method for selectively destroying tumor cells by (photo)-thermoablation. One inherent limitation to NP-mediated PTT is that the nanoparticles must arrive at the site of action to exert their function and this typically involves cellular internalization. Here we report the use of the Keggin-type polyoxometalate (POM) phosphotungstic acid (PTA) as an inorganic gelling agent for the encapsulation of plasmonic gold nanorods (AuNRs) inside a biocompatible and cell-adhesive chitosan hydrogel matrix. These functional sub-micrometric containers are non-cytotoxic and present the ability to adhere to the cytoplasmic membranes of cells avoiding any need for cellular internalization, rendering them as highly efficient thermoablating agents of eukaryotic cells in vitro.

Idioma: Inglés

DOI: 10.3389/fchem.2018.00234

Año: 2018

Publicado en: Frontiers in chemistry 6 (2018), 234 [10 pp]
ISSN: 2296-2646

Factor impacto JCR: 3.782 (2018)

Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 53 / 172 = 0.308 (2018) - Q2 - T1

Factor impacto SCIMAGO: 1.018 - Chemistry (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/ES/CSIC/ComFuturo
Financiación: info:eu-repo/grantAgreement/ES/DGA/FSE
Financiación: info:eu-repo/grantAgreement/ES/MEC/FPU014-06249
Financiación: info:eu-repo/grantAgreement/ES/MEC/FPU015-04482

Tipo y forma: Article (Published version)

Área (Departamento): Área Química Orgánica (Dpto. Química Orgánica)