Efficient Gold(I) Acyclic Diaminocarbenes for the Synthesis of Propargylamines and Indolizines

Aliaga-Lavrijsen, M. ; Pérez Herrera, R. (Universidad de Zaragoza) ; Villacampa, M.D. (Universidad de Zaragoza) ; Gimeno, M.C.

Resumen: Mononuclear gold(I) acyclic diaminocarbenes (ADCs) were prepared by the reaction of 1, 2-cyclohexanediamine with the corresponding isocyanide complexes [AuCl(CNR)] (R = Cy, tBu). The three-component coupling of aldehydes, amines, and alkynes was investigated by using these gold(I) ADC complexes. The new gold(I) metal complexes are highly efficient catalysts for the synthesis of propargylamines and indolizines in the absence of solvent and in mild conditions. This method affords the corresponding final products with excellent yields in short reaction times. Additionally, chiral gold(I) complexes with ADCs have been prepared and tried in the enantioselective synthesis of propargylamines.

Idioma: Inglés

DOI: 10.1021/acsomega.8b01352

Año: 2018

Publicado en: ACS Omega 3, 8 (2018), 9805-9813
ISSN: 2470-1343

Factor impacto JCR: 2.584 (2018)

Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 75 / 172 = 0.436 (2018) - Q2 - T2

Factor impacto SCIMAGO: 0.754 - Chemistry (miscellaneous) (Q1) - Chemical Engineering (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA/E07-17R
Financiación: info:eu-repo/grantAgreement/ES/MINECO/CTQ2016-75816-C2-1-P
Financiación: info:eu-repo/grantAgreement/ES/MINECO/CTQ2017-88091-P

Tipo y forma: Article (Published version)

Área (Departamento): Área Química Inorgánica (Dpto. Química Inorgánica)
Área (Departamento): Área Química Orgánica (Dpto. Química Orgánica)