Different protein composition of low-calorie diet differently impacts adipokine profile irrespective of weight loss in overweight and obese women
Mateo-Gallego, R. (Universidad de Zaragoza) ; Lamiquiz-Moneo, I. ; Perez-Calahorra, S. ; Marco-Benedi, V. ; Bea, A.M. ; Baila-Rueda, L. ; Laclaustra, M. ; Penalvo, J.L. ; Civeira, F. (Universidad de Zaragoza) ; Cenarro, A.
Resumen: Background and aims: High-protein (HP) diets have shown benefits in cardiometabolic markers such as insulin or triglycerides but the responsible mechanisms are not known. We aimed to assess the effect of three energy-restricted diets with different protein contents (20%, 27%, and 35%; similar to 80% coming from animal source) on plasma adipokine concentration and its association with changes in cardiometabolic markers.
Methods: Seventy-six women (BMI 32.8 +/- 2.93) were randomized to one of three calorie-reduced diets, with protein, 20%, 27%, or 35%; carbohydrates, 50%, 43%, or 35%; and fat, 30%, for 3 months. Plasma adipokine (leptin, resistin, adiponectin, and retinol-binding protein 4; RBP4) levels were assessed.
Results: After 3 months, leptin concentration decreased in all groups without differences among them, while resistin levels remained unchanged. Adiponectin concentration heterogeneously changed in all groups (P for trend = 0.165) and resistin concentration did not significantly change. RPB4 significantly decreased by -17.5% (-31.7, -3.22) in 35%-protein diet (P for trend = 0.024 among diets). Triglycerides improved in women following the 35%-protein diet regardless of weight loss; RBP4 variation significantly influenced triglyceride concentration change by 24.9% and 25.9% when comparing 27%- and 35%- with 20%-protein diet, respectively.
Conclusions: A 35%-protein diet induced a decrease in RBP4 regardless of weight loss, which was directly associated with triglyceride concentration improvement. These findings suggest that HP diets improve the cardiometabolic profile, at least in part, through changes in adipokine secretion. Whether this beneficial effect of HP diet is due to improvements in hepatic or adipose tissue functionality should be elucidated.
Idioma: Inglés
DOI: 10.1016/j.numecd.2017.10.024
Año: 2018
Publicado en: Nutrition, Metabolism and Cardiovascular Diseases 28, 2 (2018), 133-142
ISSN: 0939-4753
Factor impacto JCR: 3.34 (2018)
Categ. JCR: CARDIAC & CARDIOVASCULAR SYSTEMS rank: 50 / 135 = 0.37 (2018) - Q2 - T2
Categ. JCR: NUTRITION & DIETETICS rank: 33 / 85 = 0.388 (2018) - Q2 - T2
Categ. JCR: ENDOCRINOLOGY & METABOLISM rank: 59 / 145 = 0.407 (2018) - Q2 - T2
Factor impacto SCIMAGO: 1.318 - Cardiology and Cardiovascular Medicine (Q1) - Nutrition and Dietetics (Q1) - Medicine (miscellaneous) (Q1) - Endocrinology, Diabetes and Metabolism (Q1)
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FIS/IIS16-0114
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI13-02507
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI15-01983
Tipo y forma: Article (PostPrint)
Área (Departamento): Área Enfermería (Dpto. Fisiatría y Enfermería)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you may not distribute the modified material.
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Methods: Seventy-six women (BMI 32.8 +/- 2.93) were randomized to one of three calorie-reduced diets, with protein, 20%, 27%, or 35%; carbohydrates, 50%, 43%, or 35%; and fat, 30%, for 3 months. Plasma adipokine (leptin, resistin, adiponectin, and retinol-binding protein 4; RBP4) levels were assessed.
Results: After 3 months, leptin concentration decreased in all groups without differences among them, while resistin levels remained unchanged. Adiponectin concentration heterogeneously changed in all groups (P for trend = 0.165) and resistin concentration did not significantly change. RPB4 significantly decreased by -17.5% (-31.7, -3.22) in 35%-protein diet (P for trend = 0.024 among diets). Triglycerides improved in women following the 35%-protein diet regardless of weight loss; RBP4 variation significantly influenced triglyceride concentration change by 24.9% and 25.9% when comparing 27%- and 35%- with 20%-protein diet, respectively.
Conclusions: A 35%-protein diet induced a decrease in RBP4 regardless of weight loss, which was directly associated with triglyceride concentration improvement. These findings suggest that HP diets improve the cardiometabolic profile, at least in part, through changes in adipokine secretion. Whether this beneficial effect of HP diet is due to improvements in hepatic or adipose tissue functionality should be elucidated.
Idioma: Inglés
DOI: 10.1016/j.numecd.2017.10.024
Año: 2018
Publicado en: Nutrition, Metabolism and Cardiovascular Diseases 28, 2 (2018), 133-142
ISSN: 0939-4753
Factor impacto JCR: 3.34 (2018)
Categ. JCR: CARDIAC & CARDIOVASCULAR SYSTEMS rank: 50 / 135 = 0.37 (2018) - Q2 - T2
Categ. JCR: NUTRITION & DIETETICS rank: 33 / 85 = 0.388 (2018) - Q2 - T2
Categ. JCR: ENDOCRINOLOGY & METABOLISM rank: 59 / 145 = 0.407 (2018) - Q2 - T2
Factor impacto SCIMAGO: 1.318 - Cardiology and Cardiovascular Medicine (Q1) - Nutrition and Dietetics (Q1) - Medicine (miscellaneous) (Q1) - Endocrinology, Diabetes and Metabolism (Q1)
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FIS/IIS16-0114
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI13-02507
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI15-01983
Tipo y forma: Article (PostPrint)
Área (Departamento): Área Enfermería (Dpto. Fisiatría y Enfermería)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you may not distribute the modified material. Exportado de SIDERAL (2024-01-11-10:59:01)
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Record created 2018-11-07, last modified 2024-01-11