000075670 001__ 75670 000075670 005__ 20200108100347.0 000075670 0248_ $$2sideral$$a104976 000075670 037__ $$aART-2018-104976 000075670 041__ $$aeng 000075670 100__ $$0(orcid)0000-0003-0088-7222$$aDoweidar, M.H.$$uUniversidad de Zaragoza 000075670 245__ $$aIn-vivo cell remote control: a mecano-electro computational study 000075670 260__ $$c2018 000075670 5060_ $$aAccess copy available to the general public$$fUnrestricted 000075670 5203_ $$aAbstract ICBB17-12: Nowadays, due to its importance for human survival, tissue andorgans regeneration have received a high attention of the scientificcommunity. For the development of this field, understanding the cellbehavior is essential forin-vivotissue and organs regeneration. Cellbehavior can be controlledin-vitro, among other stimuli, by changingthe extracellular matrix mechanical properties, applying externalforces and/or electrical field. Controlling these stimuliin-vivois nottrivial. Therefore, in this work, to remotely control the local cellenvironment, we consider a microsphere of cell size that is fabricatedfrom a piezoelectric material and charged with nanomagnetic parti-cles. This microsphere is integrated within an extracellular matrix, insuch a way, through an external magnetic field, internal forces canbe generated within the microsphere. As a result, a stiffness gradientas well as an electric field are generated around the microsphere.These cues can be controlled externally by changing the magneticfield intensity... 000075670 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/MAT2016-76039-C4-4-R 000075670 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000075670 590__ $$a2.452$$b2018 000075670 591__ $$aTOXICOLOGY$$b53 / 93 = 0.57$$c2018$$dQ3$$eT2 000075670 591__ $$aPHARMACOLOGY & PHARMACY$$b140 / 266 = 0.526$$c2018$$dQ3$$eT2 000075670 592__ $$a0.728$$b2018 000075670 593__ $$aMedicine (miscellaneous)$$c2018$$dQ2 000075670 593__ $$aToxicology$$c2018$$dQ2 000075670 593__ $$aPharmacology$$c2018$$dQ2 000075670 655_4 $$ainfo:eu-repo/semantics/conferenceObject$$vinfo:eu-repo/semantics/publishedVersion 000075670 700__ $$0(orcid)0000-0003-0509-1450$$aMousavi, S.J. 000075670 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est. 000075670 773__ $$g122, Supp. 1 (2018), 6$$pBasic Clin. Pharmacol. Toxicol.$$tBasic & clinical pharmacology & toxicology$$x1742-7835 000075670 85641 $$uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111/bcpt.12952$$zTexto completo de la revista 000075670 8564_ $$s45763$$uhttps://zaguan.unizar.es/record/75670/files/texto_completo.pdf$$yVersión publicada 000075670 8564_ $$s125127$$uhttps://zaguan.unizar.es/record/75670/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000075670 909CO $$ooai:zaguan.unizar.es:75670$$particulos$$pdriver 000075670 951__ $$a2020-01-08-09:30:53 000075670 980__ $$aARTICLE