Single phase microreactor for the continuous, high-temperature synthesis of <4¿nm superparamagnetic iron oxide nanoparticles

Uson, L. ; Arruebo, M. (Universidad de Zaragoza) ; Sebastian, V. (Universidad de Zaragoza) ; Santamaria, J. (Universidad de Zaragoza)

Resumen: The reproducibility of key nanomaterial features is essential in nanomedicine applications where small changes of physical characteristics often lead to a very different behavior. In this regard, continuous microreactors are often advocated as a means to achieve highly precise synthesis of nanomaterials. However, when the synthesis must take place at high temperatures the use of these devices becomes restricted in terms of materials and practical problems (e.g. plugging of microchannels). Here we present the continuous synthesis of ultrasmall superparamagnetic iron oxide nanoparticles (SPIONs) through a polyol-based process at high temperatures (>200 °C). The microfluidic reactor designed allows SPION production at residence times under 1 min, was able to work continuously for 8 h without channel blockage and reached high production yields by coupling microreactors using stacked plates. The effect of operating conditions was optimized to produce homogeneous particles with a narrow particle size distribution. In summary, the microreactor developed in this work enables easy-to scale up, reproducible continuous production of SPIONs.

Idioma: Inglés

DOI: 10.1016/j.cej.2017.12.024

Año: 2018

Publicado en: Chemical Engineering Journal 340 (2018), 66-72
ISSN: 1385-8947

Factor impacto JCR: 8.355 (2018)

Categ. JCR: ENGINEERING, ENVIRONMENTAL rank: 2 / 52 = 0.038 (2018) - Q1 - T1
Categ. JCR: ENGINEERING, CHEMICAL rank: 6 / 138 = 0.043 (2018) - Q1 - T1

Factor impacto SCIMAGO: 2.066 - Chemical Engineering (miscellaneous) (Q1) - Chemistry (miscellaneous) (Q1) - Industrial and Manufacturing Engineering (Q1) - Environmental Chemistry (Q1) - Engineering (miscellaneous) (Q4)

Financiación: info:eu-repo/grantAgreement/ES/DGA/FSE
Financiación: info:eu-repo/grantAgreement/EC/FP7/321642/EU/Development of a microfluidic platform to produce nanomaterials and assessment on new nanotechnology applications/PLATFORM2NANO
Financiación: info:eu-repo/grantAgreement/EC/FP7/614715/EU/A Photo-triggered On-demand Drug Delivery System for Chronic Pain/NANOHEDONISM

Tipo y forma: Article (PostPrint)

Área (Departamento): Área Ingeniería Química (Dpto. Ing.Quím.Tecnol.Med.Amb.)