Self-assembling hybrid linear-dendritic block copolymers: The design of nano-carriers for lipophilic antitumoral drugs

Fedeli, E. ; Lancelot, A. ; Dominguez, J.M. ; Serrano, J.L. (Universidad de Zaragoza) ; Calvo, P. ; Sierra, T. (Universidad de Zaragoza)

Resumen: Two series of amphiphilic block copolymers with a hybrid linear-dendritic structure are presented. The compounds consisted of a hydrophilic poly (ethylene glycol) (PEG) block and a 2, 2 ' -bis(hydroxymethyl)propionic acid (bis-MPA) dendron functionalized with stearic acid chains that impart a hydrophobic nature to the block. Different self-assembled nanostructures with a hydrophobic interior and a hydrophilic external part were obtained depending on the length of the PEG chain (M n = 2000 and M n = 5000) and the generation of the bis-MPA dendron. The materials were characterized by transmission electron microscopy (TEM). The shapes of the aggregates ranged from spherical or cylindrical micelles to flexible bilayers. The hydrophobic core enabled these nanostructures to encapsulate the water-insoluble drug plitidepsin. The efficacy of these new plitidepsin-containing carriers was evaluated in four cancer cell-lines and they showed similar anticancer activity to the current standard drug formulation.

Idioma: Inglés

DOI: 10.3390/nano9020161

Año: 2019

Publicado en: Nanomaterials 9, 2 (2019), 161 [14 pp]
ISSN: 2079-4991

Factor impacto JCR: 4.324 (2019)

Categ. JCR: NANOSCIENCE & NANOTECHNOLOGY rank: 42 / 103 = 0.408 (2019) - Q2 - T2
Categ. JCR: MATERIALS SCIENCE, MULTIDISCIPLINARY rank: 89 / 314 = 0.283 (2019) - Q2 - T1

Factor impacto SCIMAGO: 0.858 - Materials Science (miscellaneous) (Q1) - Chemical Engineering (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA/E47-17R
Financiación: info:eu-repo/grantAgreement/EC/FP7/215884/EU/Functional liquid Crystalline dendrimers: Synthesis of New Materials, Resource for New Applications/DENDREAMERS
Financiación: info:eu-repo/grantAgreement/ES/MECD/FPU12-05210
Financiación: info:eu-repo/grantAgreement/ES/MINECO-FEDER/CTQ2015-70174-P
Financiación: info:eu-repo/grantAgreement/ES/MINECO-FEDER/MAT2015-66208-C3-1-P

Tipo y forma: Article (Published version)

Área (Departamento): Área Química Orgánica (Dpto. Química Orgánica)