000078186 001__ 78186
000078186 005__ 20200716101524.0
000078186 0247_ $$2doi$$a10.1155/2019/9890831
000078186 0248_ $$2sideral$$a110676
000078186 037__ $$aART-2019-110676
000078186 041__ $$aeng
000078186 100__ $$aPosarelli, C.
000078186 245__ $$aTwenty-Four-Hour Contact Lens Sensor Monitoring of Aqueous Humor Dynamics in Surgically or Medically Treated Glaucoma Patients
000078186 260__ $$c2019
000078186 5060_ $$aAccess copy available to the general public$$fUnrestricted
000078186 5203_ $$aAim. This study assessed the 24 h circadian rhythm of intraocular pressure (IOP) using a contact lens sensor in three groups of patients with open-angle glaucoma. Methods. This study was a monocentric, cross-sectional, nonrandomized, prospective, pilot study. Eighty-nine patients were enrolled: 29 patients previously underwent an Ex-PRESS mini glaucoma device procedure (Group 1), 28 patients previously underwent Hydrus microstent implantation (Group 2), and 32 patients were currently being treated medically for primary open-angle glaucoma (Group 3). Circadian rhythm patterns were considered with five circadian indicators: fluctuation ranges, maximum, minimum, acrophase (time of peak value), and bathyphase (time of trough value). A two-tailed Mann-Whitney U-test was used to evaluate differences between groups. Results. All subjects exhibited a circadian rhythm and a nocturnal pattern. The signal fluctuation range was significantly smaller in the surgical groups than in the medically treated group (Group 1 vs. Group 3, p=0.003; Group 2 vs. Group 3, p=0.010). Subjects who underwent the Ex-PRESS procedure (Group 1) exhibited significant differences compared with the drug therapy group (Group 3) with regard to the minimum value (p=0.015), acrophase (p=0.009), and bathyphase (p=0.002). The other circadian indicators were not significantly different among groups. Conclusions. Patients who underwent IOP-lowering surgery had an intrinsic nyctohemeral rhythm. Both surgical procedures, Ex-PRESS and Hydrus, were associated with smaller signal fluctuations compared with medical treatment.
000078186 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000078186 590__ $$a1.447$$b2019
000078186 591__ $$aOPHTHALMOLOGY$$b41 / 60 = 0.683$$c2019$$dQ3$$eT3
000078186 591__ $$aMEDICINE, RESEARCH & EXPERIMENTAL$$b116 / 138 = 0.841$$c2019$$dQ4$$eT3
000078186 592__ $$a0.828$$b2019
000078186 593__ $$aOphthalmology$$c2019$$dQ2
000078186 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000078186 700__ $$aOrtenzio, P.
000078186 700__ $$0(orcid)0000-0002-2914-2593$$aFerreras, A.$$uUniversidad de Zaragoza
000078186 700__ $$aToro, M.D.
000078186 700__ $$aPassani, A.
000078186 700__ $$aLoiudice, P.
000078186 700__ $$aOddone, F.
000078186 700__ $$aCasini, G.
000078186 700__ $$aFigus, M.
000078186 7102_ $$11004$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Oftalmología
000078186 773__ $$g2019 (2019), 9890831 [10 pp]$$pJ. Ophthalmol.$$tJournal of Ophthalmology$$x2090-004X
000078186 8564_ $$s646058$$uhttps://zaguan.unizar.es/record/78186/files/texto_completo.pdf$$yVersión publicada
000078186 8564_ $$s92648$$uhttps://zaguan.unizar.es/record/78186/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000078186 909CO $$ooai:zaguan.unizar.es:78186$$particulos$$pdriver
000078186 951__ $$a2020-07-16-09:29:12
000078186 980__ $$aARTICLE