Cardiovascular risk biomarkers and metabolically unhealthy status in prepubertal children: Comparison of definitions

Rupérez, A.I. (Universidad de Zaragoza) ; Olza, J. ; Gil-Campos, M. ; Leis, R. ; Bueno, G. (Universidad de Zaragoza) ; Aguilera, C.M. ; Gil, A. ; Moreno, L.A. (Universidad de Zaragoza)

Resumen: Background and aims: The early onset of cardio-metabolic abnormalities, known as metabolically unhealthy (MU) status, is highly associated with obesity and cardiovascular disease (CVD), as well as with increased morbidity and mortality later in life. Given the lack of a consensus MU classification for prepubertal children, we aimed to compare available MU definitions in terms of their association with CVD risk biomarkers.
Methods and results: A total of 930 prepubertal children (622 with overweight/obesity, 462 males) aged 5–10.9 years were recruited, anthropometric measures were taken and biomarkers were analyzed. Children were classified using eight MU definitions based on different cut-offs for blood pressure, triacylglycerides, high-density lipoprotein cholesterol, glucose and homeostasis model assessment for insulin resistance (HOMA-IR). MU prevalence in children with overweight/obesity ranged between 30% and 60% across definitions. Plasma concentrations of resistin, leptin, myeloperoxidase (MPO) and total plasminogen activator inhibitor 1 (tPAI-1) were higher, and those of adiponectin were lower, in MU compared to MH children with overweight/obesity. Linear regression analyses confirmed the contribution of MPO and tPAI-1 concentrations to MU status, with most significant results derived from definitions that use age and sex-specific criteria and that account for HOMA-IR.
Conclusion: Plasma concentrations of MPO and tPAI-1 are increased in prepubertal MU children irrespective of having normal-weight or overweight/obesity. Inclusion of age and sex-specific cut-offs for cardio-metabolic components as well as insulin resistance criteria increases the quality of MU definitions as seen by their stronger association with CVD biomarkers concentrations.

Idioma: Inglés

DOI: 10.1016/j.numecd.2018.02.006

Año: 2018

Publicado en: NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES 28, 5 (2018), 524-530
ISSN: 0939-4753

Factor impacto JCR: 3.34 (2018)

Categ. JCR: CARDIAC & CARDIOVASCULAR SYSTEMS rank: 50 / 136 = 0.368 (2018) - Q2 - T2
Categ. JCR: NUTRITION & DIETETICS rank: 33 / 86 = 0.384 (2018) - Q2 - T2
Categ. JCR: ENDOCRINOLOGY & METABOLISM rank: 59 / 145 = 0.407 (2018) - Q2 - T2

Factor impacto SCIMAGO: 1.318 - Cardiology and Cardiovascular Medicine (Q1) - Nutrition and Dietetics (Q1) - Medicine (miscellaneous) (Q1) - Endocrinology, Diabetes and Metabolism (Q1)

Financiación: info:eu-repo/grantAgreement/ES/CIBERObn/CB15-00043
Financiación: info:eu-repo/grantAgreement/ES/CIBERObn/CB15-00131
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI11-02042
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/RD08-0072-0028
Financiación: info:eu-repo/grantAgreement/ES/MINECO/FJCI-2014-19795

Tipo y forma: Article (PostPrint)

Área (Departamento): Área Enfermería (Dpto. Fisiatría y Enfermería)
Área (Departamento): Área Pediatría (Dpto. Pediatría Radiol.Med.Fís)