Effect of surface chemistry and associated protein corona on the long-term biodegradation of iron oxide nanoparticles in Vivo

Stepien, G. ; Moros, M. (Universidad de Zaragoza) ; Pérez-Hernández, M. ; Monge, M. ; Gutiérrez, L. (Universidad de Zaragoza) ; Fratila, R.M. ; Las Heras, M.D. (Universidad de Zaragoza) ; Menao Guillén, S. (Universidad de Zaragoza) ; Puente Lanzarote, J.J. ; Solans, C. ; Pardo, J. (Universidad de Zaragoza) ; Martínez De La Fuente, J. (Universidad de Zaragoza)

Resumen: The protein corona formed on the surface of a nanoparticle in a biological medium determines its behavior in vivo. Herein, iron oxide nanoparticles containing the same core and shell, but bearing two different surface coatings, either glucose or poly(ethylene glycol), were evaluated. The nanoparticles' protein adsorption, in vitro degradation, and in vivo biodistribution and biotransformation over four months were investigated. Although both types of nanoparticles bound similar amounts of proteins in vitro, the differences in the protein corona composition correlated to the nanoparticles biodistribution in vivo. Interestingly, in vitro degradation studies demonstrated faster degradation for nanoparticles functionalized with glucose, whereas the in vivo results were opposite with accelerated biodegradation and clearance of the nanoparticles functionalized with poly(ethylene glycol). Therefore, the variation in the degradation rate observed in vivo could be related not only to the molecules attached to the surface, but also with the associated protein corona, as the key role of the adsorbed proteins on the magnetic core degradation has been demonstrated in vitro.

Idioma: Inglés

DOI: 10.1021/acsami.7b18648

Año: 2018

Publicado en: ACS Applied Materials & Interfaces 10, 5 (2018), 4548-4560
ISSN: 1944-8244

Factor impacto JCR: 8.456 (2018)

Categ. JCR: NANOSCIENCE & NANOTECHNOLOGY rank: 16 / 94 = 0.17 (2018) - Q1 - T1
Categ. JCR: MATERIALS SCIENCE, MULTIDISCIPLINARY rank: 27 / 293 = 0.092 (2018) - Q1 - T1

Factor impacto SCIMAGO: 2.596 - Materials Science (miscellaneous) (Q1) - Nanoscience and Nanotechnology (Q1) - Medicine (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA/Fondo Social DGA-grupos DGA
Financiación: info:eu-repo/grantAgreement/EC/FP7/239931/EU/Multifunctional Magnetic Nanoparticles: Towards Smart Drugs Design/NANOPUZZLE
Financiación: info:eu-repo/grantAgreement/EC/H2020/657215/EU/Cell-surface immobilized vs. internalized magnetic nanoparticles for magnetic hyperthermia studies/OUTstandINg
Financiación: info:eu-repo/grantAgreement/EC/H2020/660228/EU/Profiling gene expression in Hydra vulgaris following Gold Nanoparticle-mediated hyperthermia/HyHeat
Financiación: info:eu-repo/grantAgreement/ES/MINECO/RYC-2014-15512
Financiación: info:eu-repo/grantAgreement/ES/MINECO/SAF2014-54763-C2-1-R
Financiación: info:eu-repo/grantAgreement/ES/MINECO/SAF2014-54763-C2-2-R
Financiación: info:eu-repo/grantAgreement/ES/UZ/JIUZ-2014-CIE-03

Tipo y forma: Article (PostPrint)

Área (Departamento): Área Química Analítica (Dpto. Química Analítica)
Área (Departamento): Área Sanidad Animal (Dpto. Patología Animal)
Área (Departamento): Área Inmunología (Dpto. Microb.Med.Pr.,Sal.Públ.)
Área (Departamento): Área Química Orgánica (Dpto. Química Orgánica)
Área (Departamento): Area Toxicología (Dpto. Anat.Pat.Med.Leg.For.To.)