Protein hydrolysates from fenugreek (Trigonella foenum graecum) as nutraceutical molecules in colon cancer treatment
Allaoui, A. ; Gascón, S. (Universidad de Zaragoza) ; Benomar, S. ; Quero, J. ; Osada, J. (Universidad de Zaragoza) ; Nasri, M. ; Rodríguez-Yoldi, M.J. (Universidad de Zaragoza) ; Boualga, A.
Resumen: The application of plant extracts for therapeutic purposes has been used in traditional medicine since the plants are a source of a great variety of chemical compounds that possess biological activity. Actually, the effect of these extracts on diseases such as cancer is being widely studied. Colorectal adenocarcinoma is one of the main causes of cancer related to death and the second most prevalent carcinoma in Western countries. The aim of this work is to study the possible effect of two fenugreek (Trigonella foenum graecum) protein hydrolysates on treatment and progression of colorectal cancer. Fenugreek proteins from seeds were hydrolysed by using two enzymes separately, which are named Purafect and Esperase, and were then tested on differentiated and undifferentiated human colonic adenocarcinoma Caco2/TC7 cells. Both hydrolysates did not affect the growth of differentiated cells, while they caused a decrease in undifferentiated cell proliferation by early apoptosis and cell cycle arrest in phase G1. This was triggered by a mitochondrial membrane permeabilization, cytochrome C release to cytoplasm, and caspase-3 activation. In addition, the hydrolysates of fenugreek proteins displayed antioxidant activity since they reduce the intracellular levels of ROS. These findings suggest that fenugreek protein hydrolysates could be used as nutraceutical molecules in colorectal cancer treatment.
Idioma: Inglés
DOI: 10.3390/nu11040724
Año: 2019
Publicado en: Nutrients 11, 4 (2019), 724 [15 pp]
ISSN: 2072-6643
Factor impacto JCR: 4.546 (2019)
Categ. JCR: NUTRITION & DIETETICS rank: 17 / 89 = 0.191 (2019) - Q1 - T1
Factor impacto SCIMAGO: 1.329 - Nutrition and Dietetics (Q1) - Food Science (Q1)
Financiación: info:eu-repo/grantAgreement/ES/DGA/A32
Financiación: info:eu-repo/grantAgreement/ES/DGA/B16-R17
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/CB06-03-1012
Financiación: info:eu-repo/grantAgreement/ES/MINECO/SAF2016-75441-R
Financiación: info:eu-repo/grantAgreement/EUR/SUDOE/INTERREG/Redvalue-SOE1-PI-E0123
Tipo y forma: Article (Published version)
Área (Departamento): Área Fisiología (Dpto. Farmacología y Fisiolog.)
Área (Departamento): Área Técnica. Lab. y Talleres (Dpto. Patología Animal)
Área (Departamento): Área Bioquímica y Biolog.Mole. (Dpto. Bioq.Biolog.Mol. Celular)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
Exportado de SIDERAL (2020-07-16-09:07:54)
Idioma: Inglés
DOI: 10.3390/nu11040724
Año: 2019
Publicado en: Nutrients 11, 4 (2019), 724 [15 pp]
ISSN: 2072-6643
Factor impacto JCR: 4.546 (2019)
Categ. JCR: NUTRITION & DIETETICS rank: 17 / 89 = 0.191 (2019) - Q1 - T1
Factor impacto SCIMAGO: 1.329 - Nutrition and Dietetics (Q1) - Food Science (Q1)
Financiación: info:eu-repo/grantAgreement/ES/DGA/A32
Financiación: info:eu-repo/grantAgreement/ES/DGA/B16-R17
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/CB06-03-1012
Financiación: info:eu-repo/grantAgreement/ES/MINECO/SAF2016-75441-R
Financiación: info:eu-repo/grantAgreement/EUR/SUDOE/INTERREG/Redvalue-SOE1-PI-E0123
Tipo y forma: Article (Published version)
Área (Departamento): Área Fisiología (Dpto. Farmacología y Fisiolog.)
Área (Departamento): Área Técnica. Lab. y Talleres (Dpto. Patología Animal)
Área (Departamento): Área Bioquímica y Biolog.Mole. (Dpto. Bioq.Biolog.Mol. Celular)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. Exportado de SIDERAL (2020-07-16-09:07:54)
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Record created 2019-05-09, last modified 2020-07-16