Disappearance of recurrent pancreatitis after splenectomy in familial chylomicronemia syndrome

Marco-Benedí, V. ; Lamiquiz-Moneo, I. ; Álvarez-Sala, L.A. ; Civeira, F. (Universidad de Zaragoza)

Resumen: Background and aims: Recurrent pancreatitis is a severe complication of familial chylomicronemia syndrome (FCS) mainly secondary to lipoprotein lipase deficiency. The mechanism and interindividual variability of pancreatitis in FCS are not fully understood, but abnormalities in the drainage system of pancreatic veins could be involved.
Methods and results: Two cases of typical FCS are described with a past history of recurrent pancreatitis that dramatically improved after splenectomy performed in both cases for reasons non-related to FCS.
Conclusions: These are the first reports of the disappearance of pancreatitis after splenectomy in FCS and they should be considered of anecdotal nature at this time. The disappearance of pancreatitis following splenectomy could be in part due to subsequent improvements in pancreatic drainage. Extrahepatic portal hypertension induced by hypertriglyceridemic splenomegaly leading to pancreatic congestion could also be a contributing factor.

Idioma: Inglés

DOI: 10.1016/j.atherosclerosis.2018.06.870

Año: 2018

Publicado en: Atherosclerosis 275 (2018), 342-345
ISSN: 0021-9150

Factor impacto JCR: 4.255 (2018)

Categ. JCR: PERIPHERAL VASCULAR DISEASE rank: 12 / 65 = 0.185 (2018) - Q1 - T1
Categ. JCR: CARDIAC & CARDIOVASCULAR SYSTEMS rank: 37 / 136 = 0.272 (2018) - Q2 - T1

Factor impacto SCIMAGO: 1.748 - Cardiology and Cardiovascular Medicine (Q1)

Financiación: info:eu-repo/grantAgreement/ES/ISCIII-ERDF/CIBERCV-CB16-11-00451
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FIS/IIS16-0114
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FIS/PIE16-00022
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI15-01983

Tipo y forma: Article (PostPrint)

Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)