Estudio de la liberación remota de fármacos utilizando ferrogeles bajo la acción de campos magnéticos alternos

Bruvera, Ignacio Javier
Goya, Gerardo Fabián (dir.)

Universidad de Zaragoza, CIEN, 2012
Física de la Materia Condensada department, Física de la Materia Condensada area

Máster Universitario en Física y Tecnologías Físicas

Abstract: A dedicated device was built with the purpose of studing the remotely controlled drug release of a temperature sensitive hydrogel in a water flow. Samples of the hydrogel (semi-interpenetrating polymer networks constituted by alginate and PNIPAAm) with in situ synthesized magnetite nanoparticles (average size 10nm) were characterised by TEM, STEM/EDS, SEM, VSM and power dissipation measurements. These results were used to design and construct a system able to measure the drug release of the samples in a water flow when exposed to an external RF field. The device was calibrated to obtain absolute values of drug concentration in the water flow in real time by a built-in photometer. Vitamin B12 was used as model drug. First results indicate a good response of both the sample and the device. Field induced drug liberation events were clearly recorded. A liberated B12 mass in the order of 10ng was calculated for each event. Further experiments are necessary for a complete characterization of the drug release process.

Free keyword(s): hydrogels ; drug release ; magnetic nanoparticles
Tipo de Trabajo Académico: Trabajo Fin de Master

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