000008189 001__ 8189
000008189 005__ 20170831220401.0
000008189 037__ $$aTAZ-TFM-2012-287
000008189 041__ $$aeng
000008189 1001_ $$aBruvera, Ignacio Javier
000008189 24500 $$aEstudio de la liberación remota de fármacos utilizando ferrogeles bajo la acción de campos magnéticos alternos
000008189 260__ $$aZaragoza$$bUniversidad de Zaragoza$$c2012
000008189 506__ $$aby-nc-sa$$bCreative Commons$$c3.0$$uhttp://creativecommons.org/licenses/by-nc-sa/3.0/
000008189 520__ $$aA dedicated device was built with the purpose of studing the remotely controlled drug release of a temperature sensitive hydrogel in a water flow. Samples of the hydrogel (semi-interpenetrating polymer networks constituted by alginate and PNIPAAm) with in situ synthesized magnetite nanoparticles (average size 10nm) were characterised by TEM, STEM/EDS, SEM, VSM and power dissipation measurements. These results were used to design and construct a system able to measure the drug release of the samples in a water flow when exposed to an external RF field. The device was calibrated to obtain absolute values of drug concentration in the water flow in real time by a built-in photometer. Vitamin B12 was used as model drug. First results indicate a good response of both the sample and the device. Field induced drug liberation events were clearly recorded. A liberated B12 mass in the order of 10ng was calculated for each event. Further experiments are necessary for a complete characterization of the drug release process.
000008189 521__ $$aMáster Universitario en Física y Tecnologías Físicas
000008189 540__ $$aDerechos regulados por licencia Creative Commons
000008189 6531_ $$ahydrogels
000008189 6531_ $$adrug release
000008189 6531_ $$amagnetic nanoparticles
000008189 700__ $$aGoya, Gerardo Fabián$$edir.
000008189 7102_ $$aUniversidad de Zaragoza$$bFísica de la Materia Condensada$$cFísica de la Materia Condensada
000008189 8560_ $$f645855@celes.unizar.es
000008189 8564_ $$s9949184$$uhttps://zaguan.unizar.es/record/8189/files/TAZ-TFM-2012-287.pdf$$yMemoria (eng)$$zMemoria (eng)
000008189 909CO $$ooai:zaguan.unizar.es:8189$$ptrabajos-fin-master$$pdriver
000008189 950__ $$a
000008189 980__ $$aTAZ$$bTFM$$cCIEN