Triggering antitumoural drug release and gene expression by magnetic hyperthermia

Moros, M. (Universidad de Zaragoza) ; Idiago-López, J. ; Asín, L. (Universidad de Zaragoza) ; Moreno-Antolín, E. ; Beola, L. ; Grazú, V. (Universidad de Zaragoza) ; Fratila, R.M. ; Gutiérrez, L. (Universidad de Zaragoza) ; de la Fuente, J.M. (Universidad de Zaragoza)

Resumen: Magnetic nanoparticles (MNPs) are promising tools for a wide array of biomedical applications. One of their most outstanding properties is the ability to generate heat when exposed to alternating magnetic fields, usually exploited in magnetic hyperthermia therapy of cancer. In this contribution, we provide a critical review of the use of MNPs and magnetic hyperthermia as drug release and gene expression triggers for cancer therapy. Several strategies for the release of chemotherapeutic drugs from thermo-responsive matrices are discussed, providing representative examples of their application at different levels (from proof of concept to in vivo applications). The potential of magnetic hyperthermia to promote in situ expression of therapeutic genes using vectors that contain heat-responsive promoters is also reviewed in the context of cancer gene therapy.

Idioma: Inglés

DOI: 10.1016/j.addr.2018.10.004

Año: 2018

Publicado en: ADVANCED DRUG DELIVERY REVIEWS 138 (2018), 326 - 343
ISSN: 0169-409X

Factor impacto JCR: 15.519 (2018)

Categ. JCR: PHARMACOLOGY & PHARMACY rank: 3 / 266 = 0.011 (2018) - Q1 - T1

Factor impacto SCIMAGO: 4.163 - Pharmaceutical Science (Q1)

Financiación: info:eu-repo/grantAgreement/ES/MINECO/RYC-2014-15512
Financiación: info:eu-repo/grantAgreement/ES/MINECO/RYC-2015-17640

Tipo y forma: Article (PostPrint)

Área (Departamento): Área Química Analítica (Dpto. Química Analítica)
Área (Departamento): Área Química Orgánica (Dpto. Química Orgánica)