Rapid subacute myelopathy following kidney transplantation from HTLV-1 donors: role of immunosuppresors and failure of antiretrovirals
Roc, L. ; de Mendoza, C. ; Fernandez-Alonso, M. ; Reina, G. ; Soriano, V. ; Rodriguez, C. ; Vera, M. ; del Romero, J. ; Marcaida, G. ; Ocete, M.D. ; Caballero, E. ; Molina, I. ; Aguilera, A. ; Rodriguez-Calvino, J.J. ; Navarro, D. ; Rivero, C. ; Vilarino, M.D. ; Benito, R. (Universidad de Zaragoza) ; Algarate, S. ; Gil, J. ; de Lejarazu, R.O. ; Rojo, S. ; Eiros, J.M. ; San Miguel, A. ; Manzardo, C. ; Miro, J.M. ; Garcia, J. ; Paz, I. ; Poveda, E. ; Calderon, E. ; Escudero, D. ; Trigo, M. ; Diz, J. ; Garcia-Campello, M. ; Rodriguez-Iglesias, M. ; Hernandez-Betancor, A. ; Martin, A.M. ; Ramos, J.M. ; Gimeno, A. ; Gutierrez, F. ; Rodriguez, J.C. ; Sanchez, V. ; Gomez-Hernando, C. ; Cilla, G. ; Perez-Trallero, E. ; Lopez-Aldeguer, J. ; Fernandez-Pereira, L. ; Niubo, J. ; Hernandez, M. ; Lopez-Lirola, A.M. ; Gomez-Sirvent, J.L. ; Force, L. ; Cifuentes, C. ; Perez, S. ; Morano, L. ; Raya, C. ; Gonzalez-Praetorius, A. ; Perez, J.L. ; Penaranda, M. ; Hernaez-Crespo, S. ; Montejo, J.M. ; Martinez-Sapina, A. ; Viciana, I. ; Cabezas, T. ; Lozano, A. ; Fernandez, J.M. ; Garcia-Bermejo, I. ; Gaspar, G. ; Garcia, R. ; Gorgolas, M. ; Vegas, C. ; Blas, J. ; Miralles, P. ; Valeiro, M. ; Aldamiz, T. ; Margall, N. ; Guardia, C. ; do Pico, E. ; Polo, I. ; Aguinaga, A. ; Ezpeleta, C. ; Sauleda, S. ; Piron, M. ; Gonzalez, R. ; Barea, L. ; Jimenez, A. ; Blanco, L. ; Suarez, A. ; Rodriguez-Avial, I. ; Perez-Rivilla, A. ; Parra, P. ; Fernandez, M. ; Trevino, A. ; Requena, S. ; Benitez-Gutierrez, L. ; Cuervas-Mons, V. ; Barreiro, P. ; Corral, O. ; Gomez-Gallego, F.
Resumen: Two kidney transplant recipients from a single donor became infected with HTLV-1 (human T-lymphotropic virus type 1) in Spain. One developed myelopathy 8 months following surgery despite early prescription of antiretroviral therapy. The allograft was removed from the second recipient at month 8 due to rejection and immunosuppressors discontinued. To date, 3 years later, this patient remains infected but asymptomatic. HTLV-1 infection was recognized retrospectively in the donor, a native Spaniard who had sex partners from endemic regions. Our findings call for a reappraisal of screening policies on donor-recipient organ transplantation. Based on the high risk of disease development and the large flux of persons from HTLV-1 endemic regions, pre-transplant HTLV-1 testing should be mandatory in Spain.
Idioma: Inglés
DOI: 10.1177/2049936119868028
Año: 2019
Publicado en: Therapeutic Advances in Infectious Disease 6 (2019), 1-8
ISSN: 2049-9361
Tipo y forma: Article (Published version)
Área (Departamento): Área Microbiología (Dpto. Microb.Med.Pr.,Sal.Públ.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes.
Exportado de SIDERAL (2023-09-13-10:45:28)
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Idioma: Inglés
DOI: 10.1177/2049936119868028
Año: 2019
Publicado en: Therapeutic Advances in Infectious Disease 6 (2019), 1-8
ISSN: 2049-9361
Tipo y forma: Article (Published version)
Área (Departamento): Área Microbiología (Dpto. Microb.Med.Pr.,Sal.Públ.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. Exportado de SIDERAL (2023-09-13-10:45:28)
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Record created 2019-11-13, last modified 2023-09-14