Impact of targeted attack on the spontaneous activity in spatial and biologically-inspired neuronal networks

Faci-Lázaro, Sergio (Universidad de Zaragoza) ; Soriano, Jordi ; Gómez-Gardeñes, Jesús (Universidad de Zaragoza)

Resumen: We study the structural and dynamical consequences of damage in spatial neuronal networks. Inspired by real in vitro networks, we construct directed networks embedded in a two-dimensional space and follow biological rules for designing the wiring of the system. As a result, synthetic cultures display strong metric correlations similar to those observed in real experiments. In its turn, neuronal dynamics is incorporated through the Izhikevich model adopting the parameters derived from observation in real cultures. We consider two scenarios for damage, targeted attacks on those neurons with the highest out-degree and random failures. By analyzing the evolution of both the giant connected component and the dynamical patterns of the neurons as nodes are removed, we observe that network activity halts for a removal of 50% of the nodes in targeted attacks, much lower than the 70% node removal required in the case of random failures. Notably, the decrease of neuronal activity is not gradual. Both damage scenarios portray "boosts" of activity just before full silencing that are not present in equivalent random (Erdös-Rényi) graphs. These boosts correspond to small, spatially compact subnetworks that are able to maintain high levels of activity. Since these subnetworks are absent in the equivalent random graphs, we hypothesize that metric correlations facilitate the existence of local circuits sufficiently integrated to maintain activity, shaping an intrinsic mechanism for resilience.

Idioma: Inglés

DOI: 10.1063/1.5099038

Año: 2019

Publicado en: CHAOS 29, 8 (2019), 083126 1-11
ISSN: 1054-1500

Factor impacto JCR: 2.832 (2019)

Categ. JCR: PHYSICS, MATHEMATICAL rank: 5 / 55 = 0.091 (2019) - Q1 - T1
Categ. JCR: MATHEMATICS, APPLIED rank: 16 / 260 = 0.062 (2019) - Q1 - T1

Factor impacto SCIMAGO: 0.934 - Medicine (miscellaneous) (Q1) - Mathematical Physics (Q1) - Statistical and Nonlinear Physics (Q1) - Physics and Astronomy (miscellaneous) (Q1) - Applied Mathematics (Q2)

Financiación: info:eu-repo/grantAgreement/ES/DGA/FENOL-GROUP
Financiación: info:eu-repo/grantAgreement/ES/MINECO/FIS2015-71582-C2
Financiación: info:eu-repo/grantAgreement/ES/MINECO/FIS2016-78507-C2-2-P
Financiación: info:eu-repo/grantAgreement/ES/MINECO/FIS2017-87519-P
Financiación: info:eu-repo/grantAgreement/ES/MINECO/FIS2017-90782-REDT

Tipo y forma: Article (Published version)

Área (Departamento): Área Física Materia Condensada (Dpto. Física Materia Condensa.)