000086361 001__ 86361
000086361 005__ 20200716101555.0
000086361 0247_ $$2doi$$a10.1155/2019/2890193
000086361 0248_ $$2sideral$$a115063
000086361 037__ $$aART-2019-115063
000086361 041__ $$aeng
000086361 100__ $$0(orcid)0000-0002-1609-5994$$aSatue, M.$$uUniversidad de Zaragoza
000086361 245__ $$aFunctional Evaluation of the Visual Pathway in Patients with Multiple Sclerosis Using a Multifunction Stimulator Monitor
000086361 260__ $$c2019
000086361 5060_ $$aAccess copy available to the general public$$fUnrestricted
000086361 5203_ $$aObjectives. To assess the capability of the vision monitor unit Monpack One of detecting visual function alterations in patients with multiple sclerosis (MS) and to evaluate the correlation between structural retinal parameters and functional measurements obtained with this device. Methods. Forty-eight patients with MS and 46 healthy controls were included in a cross-sectional study. All participants underwent a complete functional evaluation of the visual pathway, which included low-contrast visual acuity (LCVA), contrast sensitivity vision (CSV), automated perimetry, multifocal visual evoked potentials (mfVEPs), and pattern electroretinogram (ERG). All tests were performed using the vision monitor unit Monpack One (Metrovision, France), a multifunction stimulator device. Retinal structural measurements were obtained in all subjects using Triton swept source optical coherence tomography (Topcon, Japan). Results. Patients with MS presented reduced low-contrast VA (p<0.001) and reduced CSV at medium (p=0.001, p=0.013) and low (p=0.001, p=0.002) spatial frequencies. All visual field parameters were found to be altered in MS patients compared with controls (<= 0.001). Patients with MS presented lower amplitude of the P100 waveform of the mfVEP in areas corresponding to central (p<0.001), inferonasal (p=0.001), and inferotemporal (p=0.003) retina. The pattern ERG did not show significant differences. Significant correlations were observed between structural retinal measurements and functional parameters, especially between the inner macular areas and measurements corresponding to contrast sensitivity and perimetry indexes. Conclusions. Patients with MS present visual dysfunction detectable with the vision monitor unit Monpack One. This device may be a fast and useful tool to provide a full evaluation of axonal damage in patients with multiple sclerosis.
000086361 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/CM14-00026
000086361 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000086361 590__ $$a1.447$$b2019
000086361 591__ $$aOPHTHALMOLOGY$$b41 / 60 = 0.683$$c2019$$dQ3$$eT3
000086361 591__ $$aMEDICINE, RESEARCH & EXPERIMENTAL$$b116 / 138 = 0.841$$c2019$$dQ4$$eT3
000086361 592__ $$a0.828$$b2019
000086361 593__ $$aOphthalmology$$c2019$$dQ2
000086361 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000086361 700__ $$aJarauta, L.
000086361 700__ $$aObis, J.
000086361 700__ $$aCipres, M.
000086361 700__ $$aRodrigo, M.J.
000086361 700__ $$aAlmarcegui, C.
000086361 700__ $$aDolz, I.
000086361 700__ $$aAra, J.R.
000086361 700__ $$aMartin, J.
000086361 700__ $$0(orcid)0000-0003-2389-8282$$aPablo, L.E.$$uUniversidad de Zaragoza
000086361 700__ $$0(orcid)0000-0001-6258-2489$$aGarcia-Martin, E.$$uUniversidad de Zaragoza
000086361 7102_ $$11004$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Oftalmología
000086361 773__ $$g2019 (2019), 2890193 1-8$$pJ. Ophthalmol.$$tJournal of Ophthalmology$$x2090-004X
000086361 8564_ $$s687487$$uhttps://zaguan.unizar.es/record/86361/files/texto_completo.pdf$$yVersión publicada
000086361 8564_ $$s28591$$uhttps://zaguan.unizar.es/record/86361/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000086361 909CO $$ooai:zaguan.unizar.es:86361$$particulos$$pdriver
000086361 951__ $$a2020-07-16-09:49:09
000086361 980__ $$aARTICLE