Polypeptidic Micelles Stabilized with Sodium Alginate Enhance the Activity of Encapsulated Bedaquiline

Soria-Carrera, H. ; Lucía, A. (Universidad de Zaragoza) ; De Matteis, L. ; Aínsa, J.A. (Universidad de Zaragoza) ; de la Fuente, J.M. ; Martín-Rapún, R. (Universidad de Zaragoza)

Resumen: The coating of polypeptidic micelles with sodium alginate is described as a strategy to improve the stability of micelles for drug delivery. Bedaquiline, approved in 2012 for the treatment of multidrug resistant tuberculosis, has been used as an example of hydrophobic drug to study the loading efficiency, the release of the encapsulated drug in different media, and the in vitro antimicrobial activity of the system. Alginate coating prevents the burst release of the drug from micelles upon dilution and leads to a sustained release in all tested media. In view of possible oral administration, the alginate coated micelles show better stability in gastric and intestinal simulated media. Notably, the encapsulated bedaquiline shows increased in vitro activity against Mycobacterium tuberculosis compared to free bedaquiline.

Idioma: Inglés

DOI: 10.1002/mabi.201800397

Año: 2019

Publicado en: Macromolecular Bioscience 19, 4 (2019), 1800397 [11 pp]
ISSN: 1616-5187

Factor impacto JCR: 3.416 (2019)

Categ. JCR: POLYMER SCIENCE rank: 17 / 89 = 0.191 (2019) - Q1 - T1
Categ. JCR: BIOCHEMISTRY & MOLECULAR BIOLOGY rank: 130 / 297 = 0.438 (2019) - Q2 - T2
Categ. JCR: MATERIALS SCIENCE, BIOMATERIALS rank: 18 / 38 = 0.474 (2019) - Q2 - T2

Factor impacto SCIMAGO: 0.834 - Materials Chemistry (Q1) - Polymers and Plastics (Q1) - Biomaterials (Q2) - Bioengineering (Q2) - Biotechnology (Q2)

Financiación: info:eu-repo/grantAgreement/ES/DGA/FSE
Financiación: info:eu-repo/grantAgreement/ES/MINECO/RYC-2013-12570
Financiación: info:eu-repo/grantAgreement/ES/MINECO-FEDER/CTQ2015-66869-P

Tipo y forma: Article (PostPrint)

Área (Departamento): Área Microbiología (Dpto. Microb.Med.Pr.,Sal.Públ.)
Área (Departamento): Área Química Orgánica (Dpto. Química Orgánica)