The influence of lung microbiota on lung carcinogenesis, immunity and immunotherapy

Ramírez-Labrada, Ariel G. ; Isla, Dolores ; Artal, Angel ; Arias, Maykel ; Rezusta, Antonio (Universidad de Zaragoza) ; Pardo, Julián (Universidad de Zaragoza) ; Gálvez, Eva M.

Resumen: Microbiota have emerged as key modulators of both the carcinogenic process and the immune response against cancer cells, and, thus, it seems to influence the efficacy of immunotherapy. While most studies have focused on analyzing the influence of gut microbiota, its composition substantially differs from that in the lung. Here, we describe how microbial life in the lungs is associated with host immune status in the lungs and, thus, how the identification of the microbial populations in the lower respiratory tract rather than in the gut might be key to understanding the lung carcinogenic process and to predict the efficacy of different treatments. Understanding the influence of lung microbiota on host immunity may identify new therapeutic targets and help to design new immunotherapy approaches to treat lung cancer.

Idioma: Inglés

DOI: 10.1016/j.trecan.2019.12.007

Año: 2020

Publicado en: Trends in Cancer 6, 2 (2020), P86-97
ISSN: 2405-8033

Factor impacto JCR: 14.226 (2020)

Categ. JCR: ONCOLOGY rank: 14 / 242 = 0.058 (2020) - Q1 - T1

Factor impacto SCIMAGO: 4.174 - Oncology (Q1) - Cancer Research (Q1)

Tipo y forma: Review (Published version)

Área (Departamento): Área Microbiología (Dpto. Microb.Ped.Radio.Sal.Pú.)
Área (Departamento): Área Inmunología (Dpto. Microb.Ped.Radio.Sal.Pú.)