Adult social isolation leads to anxiety and spatial memory impairment: Brain activity pattern of COx and c-Fos

Zorzo, C. ; Méndez-López, M. (Universidad de Zaragoza) ; Méndez, M. ; Arias, J.L.

Resumen: Social isolation during adulthood is a frequent problem that leads to a large variety of adverse emotional and cognitive effects. However, most of the social isolation rodent procedures begin the separation early post-weaning. This work explores locomotor activity, anxiety-like behaviour, and spatial working memory after twelve weeks of adult social isolation. In order to study the functional contribution of selected brain areas following a working memory task, we assessed neuronal metabolic activity through quantitative cytochrome oxidase histochemistry and c-Fos immunohistochemistry. Behaviourally, we found that isolated animals (IS) showed anxiety-like behaviour and worse working memory than controls, whereas motor functions were preserved. Moreover, IS rats showed lower levels of learning-related c-Fos immunoreactivity, compared to controls, in the medial prefrontal cortex (mPFC), ventral tegmental area (VTA), and nucleus accumbens shell. In addition, the IS group showed lower neuronal metabolic activity in the mPFC, VTA, and CA1 subfield of the hippocampus. These results indicate that twelve weeks of social isolation in adult rats leads to different behavioural and brain alterations, and they highlight the importance of social support, not only in development, but also in adulthood.

Idioma: Inglés

DOI: 10.1016/j.bbr.2019.03.011

Año: 2019

Publicado en: Behavioural brain research 365 (2019), 170-177
ISSN: 0166-4328

Factor impacto JCR: 2.977 (2019)

Categ. JCR: BEHAVIORAL SCIENCES rank: 14 / 52 = 0.269 (2019) - Q2 - T1
Categ. JCR: NEUROSCIENCES rank: 143 / 271 = 0.528 (2019) - Q3 - T2

Factor impacto SCIMAGO: 1.179 - Behavioral Neuroscience (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA-FEDER/Construyendo Europa desde Aragón
Financiación: info:eu-repo/grantAgreement/ES/MINECO/PSI2015-73111-EXP
Financiación: info:eu-repo/grantAgreement/ES/MINECO/PSI2017-83893-R
Financiación: info:eu-repo/grantAgreement/ES/MINECO/PSI2017-90806-REDT

Tipo y forma: Article (PostPrint)

Área (Departamento): Área Psicobiología (Dpto. Psicología y Sociología)