The role of extracellular matrix on liver stem cell fate: A dynamic relationship in health and disease

Sánchez-Romero, N. ; Sainz-Arnal, P. ; Pla-Palacín, I. ; Royo Dachary, P. (Universidad de Zaragoza) ; Almeida, H. ; Pastor, C. ; Rubio Soto, D. ; Chico Rodriguez, M. ; Olmedo Arbizu, E. ; Bengochea Martinez, L. (Universidad de Zaragoza) ; Serrano-Aulló, T. (Universidad de Zaragoza) ; Baptista, P.M.

Resumen: The liver stem cell niche is a specialized and dynamic microenvironment with biomechanical and biochemical characteristics that regulate stem cell behavior. This is feasible due to the coordination of a complex network of secreted factors, small molecules, neural, blood inputs and extracellular matrix (ECM) components involved in the regulation of stem cell fate (self-renewal, survival, and differentiation into more mature phenotypes like hepatocytes and cholangiocytes). In this review, we describe and summarize all the major components that play essential roles in the liver stem cell niche, in particular, growth factor signaling and the biomechanical properties of the ECM.

Idioma: Inglés

DOI: 10.1016/j.diff.2019.03.001

Año: 2019

Publicado en: DIFFERENTIATION 106 (2019), 49-56
ISSN: 0301-4681

Factor impacto JCR: 2.392 (2019)

Categ. JCR: DEVELOPMENTAL BIOLOGY rank: 18 / 41 = 0.439 (2019) - Q2 - T2
Categ. JCR: CELL BIOLOGY rank: 146 / 195 = 0.749 (2019) - Q3 - T3

Factor impacto SCIMAGO: 1.017 - Cancer Research (Q2) - Molecular Biology (Q2) - Developmental Biology (Q2) - Cell Biology (Q3)

Financiación: info:eu-repo/grantAgreement/ES/DGA-FSE/C066-2014
Financiación: info:eu-repo/grantAgreement/ES/FEDER/POCTEFA-Refbio II
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI15-00563
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/i-PFIS-IFI15-00158

Tipo y forma: Review (PostPrint)

Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
Área (Departamento): Área Cirugía (Dpto. Cirugía,Ginecol.Obstetr.)
Área (Departamento): Area Anatomía Patológica (Dpto. Anat.Pat.Med.Leg.For.To.)