Effect of an alcohol-free beer enriched with isomaltulose and a resistant dextrin on insulin resistance in diabetic patients with overweight or obesity

Mateo-Gallego, R. (Universidad de Zaragoza) ; Pérez-Calahorra, S. (Universidad de Zaragoza) ; Lamiquiz-Moneo, I. ; Marco-Benedí, V. (Universidad de Zaragoza) ; Bea, A.M. ; Fumanal, A.J. ; Prieto-Martín, A. ; Laclaustra, M. (Universidad de Zaragoza) ; Cenarro, A. ; Civeira, F. (Universidad de Zaragoza)

Resumen: Background & aims: The quality of carbohydrates has an essential role in nutritional management of type 2 diabetes mellitus (T2DM) because of its substantial impact on glucose homeostasis. Alcohol-free beer has beneficial bioactive components but it has a relatively high glycemic-index so its consumption is restricted in diabetic subjects. We aimed to explore the effect of an alcohol-free beer with modified carbohydrate composition almost completely eliminating maltose and adding isomaltulose (16.5 g/day) and a resistant maltodextrin (5.28 g/day) in comparison to a regular alcohol-free beer on glycemic control of diabetic subjects with overweight or obesity. Design: We randomized 41 subjects into two groups: a) consumption of 66 cL/day of; regular alcohol-free beer for the first 10 weeks and 66 cL/day of alcohol-free beer with modified carbohydrate composition for the next 10 weeks; b) the same described intervention in opposite order. There was a washout period for 6–8 weeks between the two interventions. Participants were counseled to adhere to a healthy diet for cardiovascular health and to increase physical activity. Clinical, biochemical, anthropometric, lifestyle and satiety assessments were performed at the beginning and at the end of each period. Results: Subjects showed significantly weight loss after the two ten weeks periods (-1.69 ± 3.21% and -1.77 ± 3.70% after experimental and regular alcohol-free beers, respectively, P = 0.881). Glucose and glycated hemoglobin did not significantly change after any period. Insulin concentrations and HOMA-IR significantly decreased (-11.1 [–21.3-4.64]% and -1.92 ± 32.8% respectively) after the intake of experimental alcohol-free beer but not after regular alcohol-free beer. Reductions remained statistically significant after adjusting for weight loss, energy intake, physical activity and intervention order. Subjects reported higher satiety scores after consuming experimental alcohol-free beer. Conclusions: An alcohol-free beer including the substitution of regular carbohydrates for low doses of isomaltulose and the addition of a resistant maltodextrin within meals led to an improvement in insulin resistance in subjects with T2DM and overweight or obesity. Clinical trial registration: The clinical trial has been registered in ClinicalTrials.gov (Identifier: NCT03337828).

Idioma: Inglés

DOI: 10.1016/j.clnu.2019.02.025

Año: 2020

Publicado en: Clinical Nutrition 39, 2 (2020), 475-483
ISSN: 0261-5614

Factor impacto JCR: 7.324 (2020)

Categ. JCR: NUTRITION & DIETETICS rank: 7 / 87 = 0.08 (2020) - Q1 - T1

Factor impacto SCIMAGO: 1.915 - Nutrition and Dietetics (Q1) - Critical Care and Intensive Care Medicine (Q1)

Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI15-00114

Tipo y forma: Article (PostPrint)

Área (Departamento): Área Enfermería (Dpto. Fisiatría y Enfermería)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)