Resumen: Pathological mutations in subunits of the oxidative phosphorylation (OXPHOS) system, or inhibitors of this biochemical pathway, increase the production of vascular endothelial growth factor (VEGF) and pathological angiogenesis. In many angiogenesis-related diseases, such as retinal, rheumatoid diseases, or cancer, OXPHOS dysfunction can be found. Thus, enhancing OXPHOS might be a promising therapeutic approach for pathologic angiogenesis. Idioma: Inglés DOI: 10.1016/j.drudis.2019.03.014 Año: 2019 Publicado en: DRUG DISCOVERY TODAY 19 (2019), 30035-2 ISSN: 1359-6446 Factor impacto JCR: 7.321 (2019) Categ. JCR: PHARMACOLOGY & PHARMACY rank: 12 / 270 = 0.044 (2019) - Q1 - T1 Factor impacto SCIMAGO: 1.896 - Pharmacology (Q1) - Drug Discovery (Q1)