Oxidative phosphorylation inducers fight pathological angiogenesis

Bayona-Bafaluy, M.P. (Universidad de Zaragoza) ; Esteban, O. ; Ascaso, J. (Universidad de Zaragoza) ; Montoya, J. (Universidad de Zaragoza) ; Ruiz-Pesini, E. (Universidad de Zaragoza)
Oxidative phosphorylation inducers fight pathological angiogenesis
Resumen: Pathological mutations in subunits of the oxidative phosphorylation (OXPHOS) system, or inhibitors of this biochemical pathway, increase the production of vascular endothelial growth factor (VEGF) and pathological angiogenesis. In many angiogenesis-related diseases, such as retinal, rheumatoid diseases, or cancer, OXPHOS dysfunction can be found. Thus, enhancing OXPHOS might be a promising therapeutic approach for pathologic angiogenesis.
Idioma: Inglés
DOI: 10.1016/j.drudis.2019.03.014
Año: 2019
Publicado en: DRUG DISCOVERY TODAY 19 (2019), 30035-2
ISSN: 1359-6446

Factor impacto JCR: 7.321 (2019)
Categ. JCR: PHARMACOLOGY & PHARMACY rank: 12 / 270 = 0.044 (2019) - Q1 - T1
Factor impacto SCIMAGO: 1.896 - Pharmacology (Q1) - Drug Discovery (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA/B33-17R
Financiación: info:eu-repo/grantAgreement/ES/DGA/FEDER
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI17-00021
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI17-00166
Tipo y forma: Article (PostPrint)
Área (Departamento): Área Oftalmología (Dpto. Cirugía,Ginecol.Obstetr.)
Área (Departamento): Área Bioquímica y Biolog.Mole. (Dpto. Bioq.Biolog.Mol. Celular)


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