Colangitis esclerosante primaria y enfermedad inflamatoria intestinal: interrelación intestino-hígado
Núñez, F. P. ; Quera, P. R. ; Gomollón, F. (Universidad de Zaragoza)
Resumen: La asociación entre enfermedad inflamatoria intestinal y colangitis esclerosante primaria debe ser considerada una entidad distinta. Su asociación involucra alteraciones genéticas, epidemiológicas (mayor frecuencia en varones y sin una clara distribución geográfica) y un cuadro clínico en el que destaca con mayor frecuencia un compromiso inflamatorio subclínico, el predominio de colon derecho (demostrado por endoscopia e histología), la presencia de ileítis por reflujo y la ausencia de compromiso rectal. A su vez, existe un mayor riesgo de cáncer de colon y colangiocarcinoma. El objetivo de esta revisión es mostrar como la enfermedad inflamatoria intestinal influye en su evolución, en los requerimientos de trasplante y en la recurrencia. A su vez, señalar la evidencia actual sobre el uso de la terapia biológica en este grupo de pacientes.
The association between inflammatory bowel disease (IBD) and primary sclerosing cholangitis should be considered a distinct clinical entity. This association involves genetic abnormalities, epidemiological factors (more common in men, with no a geographical pattern) and, commonly, subclinical inflammation, predominance of the right colon (endoscopic and histological), backwash ileitis and rectal sparing. Furthermore, there is an increased risk of colorectal cancer and cholangiocarcinoma. The aim of this review is to show how IBD influences the progression of this entity, transplantation requirements and recurrence. We also discuss the current evidence on the use of biological therapy in this group of patients.
Idioma: Español
DOI: 10.1016/j.gastrohep.2019.02.004
Año: 2019
Publicado en: Gastroenterologia y Hepatologia 42, 5 (2019), 316-325
ISSN: 0210-5705
Factor impacto JCR: 1.581 (2019)
Categ. JCR: GASTROENTEROLOGY & HEPATOLOGY rank: 82 / 88 = 0.932 (2019) - Q4 - T3
Factor impacto SCIMAGO: 0.248 - Gastroenterology (Q3) - Hepatology (Q4)
Tipo y forma: Review (PostPrint)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you may not distribute the modified material.
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The association between inflammatory bowel disease (IBD) and primary sclerosing cholangitis should be considered a distinct clinical entity. This association involves genetic abnormalities, epidemiological factors (more common in men, with no a geographical pattern) and, commonly, subclinical inflammation, predominance of the right colon (endoscopic and histological), backwash ileitis and rectal sparing. Furthermore, there is an increased risk of colorectal cancer and cholangiocarcinoma. The aim of this review is to show how IBD influences the progression of this entity, transplantation requirements and recurrence. We also discuss the current evidence on the use of biological therapy in this group of patients.
Idioma: Español
DOI: 10.1016/j.gastrohep.2019.02.004
Año: 2019
Publicado en: Gastroenterologia y Hepatologia 42, 5 (2019), 316-325
ISSN: 0210-5705
Factor impacto JCR: 1.581 (2019)
Categ. JCR: GASTROENTEROLOGY & HEPATOLOGY rank: 82 / 88 = 0.932 (2019) - Q4 - T3
Factor impacto SCIMAGO: 0.248 - Gastroenterology (Q3) - Hepatology (Q4)
Tipo y forma: Review (PostPrint)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you may not distribute the modified material. Exportado de SIDERAL (2020-07-16-09:15:26)
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Record created 2020-04-15, last modified 2020-07-16