000089590 001__ 89590 000089590 005__ 20230201140446.0 000089590 0247_ $$2doi$$a10.3390/cells9030693 000089590 0248_ $$2sideral$$a117619 000089590 037__ $$aART-2020-117619 000089590 041__ $$aeng 000089590 100__ $$0(orcid)0000-0002-9647-0108$$aLamiquiz-Moneo, I. 000089590 245__ $$aEffect of Lifestyle Intervention in the Concentration of Adipoquines and Branched Chain Amino Acids in Subjects with High Risk of Developing Type 2 Diabetes: Feel4Diabetes Study 000089590 260__ $$c2020 000089590 5060_ $$aAccess copy available to the general public$$fUnrestricted 000089590 5203_ $$aIntroduction: The global prevalence of type 2 diabetes (T2D) is increasing rapidly, especially in low- and middle-income countries and has a high number of associated comorbidities. Plasmatic concentrations of branched chain amino acids (BCAA) and retinol-binding protein 4 (RBP4) have been shown to be elevated in T2D subjects in cross-sectional studies. However, the effect of lifestyle community-based interventions on BCAA and RBP4 concentrations has not yet been analyzed. Material and methods: The Feel4Diabetes study is a school and community-based intervention that identified 360 European families with a high risk of developing T2D according to the FINDRISC questionnaire. Families were randomized in control and intervention groups were followed-up from 2016 to 2018. In the Spanish families, the concentration of BCAA and RBP4 was determined in 266 subjects (115 control and 151 intervention group) that attended the three time-point assessments by colorimetric and ELISA reaction, respectively. Results: Baseline BCAA levels showed positive correlations with the FINDRISC score and glucose impairment (baseline glucose, insulin, and glycated hemoglobin), body mass index, and body weight. The participants receiving the community-based intervention showed a significant decrease in glycated hemoglobin and BCAA levels compared to the control group (p = 0.011 and p < 0.001, respectively). However, baseline RBP4 did not show significant correlations with anthropometric and glycemic parameters, and no significant change was observed in anthropometric parameters and RBP4 concentrations throughout the follow-up. Conclusion: A community-based intervention on lifestyle led to a significant reduction in BCAA levels regardless of weight loss. These findings suggest that this interventional approach could be promising in T2D prevention. 000089590 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B14-7R$$9info:eu-repo/grantAgreement/ES/FEDER/Una manera de hacer Europa$$9info:eu-repo/grantAgreement/ES/MINECO/CIBERCV$$9info:eu-repo/grantAgreement/ES/MINECO/PI15-01983$$9info:eu-repo/grantAgreement/ES/MINECO/PI18-01777 000089590 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000089590 590__ $$a6.6$$b2020 000089590 591__ $$aCELL BIOLOGY$$b53 / 195 = 0.272$$c2020$$dQ2$$eT1 000089590 592__ $$a1.22$$b2020 000089590 593__ $$aMedicine (miscellaneous)$$c2020$$dQ1 000089590 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000089590 700__ $$aBea, A.M. 000089590 700__ $$aPalacios-Perez, C. 000089590 700__ $$aDe Miguel-Etayo, P. 000089590 700__ $$aGonzalez-Gil, E.M. 000089590 700__ $$aLopez-Arino, C. 000089590 700__ $$0(orcid)0000-0001-7043-0952$$aCiveira, F.$$uUniversidad de Zaragoza 000089590 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno, L.A.$$uUniversidad de Zaragoza 000089590 700__ $$0(orcid)0000-0001-6650-8294$$aMateo-Gallego, R.$$uUniversidad de Zaragoza 000089590 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería 000089590 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina 000089590 773__ $$g9, 3 (2020), 693 [19 pp]$$pCells$$tCells$$x2073-4409 000089590 8564_ $$s384960$$uhttps://zaguan.unizar.es/record/89590/files/texto_completo.pdf$$yVersión publicada 000089590 8564_ $$s511723$$uhttps://zaguan.unizar.es/record/89590/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000089590 909CO $$ooai:zaguan.unizar.es:89590$$particulos$$pdriver 000089590 951__ $$a2023-02-01-13:46:54 000089590 980__ $$aARTICLE