000089616 001__ 89616
000089616 005__ 20210902121643.0
000089616 0247_ $$2doi$$a10.1371/journal.pone.0229856
000089616 0248_ $$2sideral$$a117422
000089616 037__ $$aART-2020-117422
000089616 041__ $$aeng
000089616 100__ $$aCarnero, E.
000089616 245__ $$aContinuous intraocular pressure monitoring in patients with obstructive sleep apnea syndrome using a contact lens sensor
000089616 260__ $$c2020
000089616 5060_ $$aAccess copy available to the general public$$fUnrestricted
000089616 5203_ $$aPurpose To analyse nocturnal intraocular pressure (IOP) fluctuations in patients with obstructive sleep apnea syndrome (OSAS) using a contact lens sensor (CLS) and to identify associations between the OSAS parameters determined by polysomnographic study (PSG) and IOP changes. Method Prospective, observational study. Twenty participants suspected of having OSAS were recruited. During PSG study, IOP was monitored using a CLS placed in the eye of the patient. The patients were classified according to the apnea-hypopnea index (AHI) in two categories, severe (>30) or mild/moderate (<30) OSAS. We evaluated several parameters determined by the IOP curves, including nocturnal elevations (acrophase) and plateau times in acrophase (PTs) defined by mathematical and visual methods. Results The IOP curves exhibited a nocturnal acrophase followed by PTs of varying extents at which the IOP remained higher than daytime measurement with small variations. We found significant differences in the length of the PTs in patients with severe OSAS compared to those with mild/moderate disease (P = 0.032/P = 0.028). We found a positive correlation between PTs and OSAS severity measured by the total number of apneic events (r = 0.681/ 0.751 P = 0.004/0.001) and AHI (r = 0.674/0.710, P = 0.004/0.002). Respiratory-related arousal and oxygen saturation also were associated significantly with the IOP PT length. Conclusions Periods of nocturnal IOP elevation lasted longer in severe OSAS patients than those with mild/moderate OSAS and correlate with the severity of the disease. The length of the nocturnal PT is also associated to respiratory parameters altered in patients with OSAS.
000089616 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/RD07-0063
000089616 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000089616 590__ $$a3.24$$b2020
000089616 591__ $$aMULTIDISCIPLINARY SCIENCES$$b26 / 73 = 0.356$$c2020$$dQ2$$eT2
000089616 592__ $$a0.99$$b2020
000089616 593__ $$aMultidisciplinary$$c2020$$dQ1
000089616 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000089616 700__ $$aBragard, J.
000089616 700__ $$aUrrestarazu, E.
000089616 700__ $$aRivas, E.
000089616 700__ $$0(orcid)0000-0002-1402-3129$$aPolo, V.$$uUniversidad de Zaragoza
000089616 700__ $$0(orcid)0000-0002-6745-7668$$aLarrosa, J.M.$$uUniversidad de Zaragoza
000089616 700__ $$aAntón, V.
000089616 700__ $$aPeláez, A.
000089616 700__ $$aMoreno-Montañés, J.
000089616 7102_ $$11013$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Oftalmología
000089616 773__ $$g15, 3 (2020), e0229856 [18 pp.]$$pPLoS One$$tPloS one$$x1932-6203
000089616 8564_ $$s1484672$$uhttps://zaguan.unizar.es/record/89616/files/texto_completo.pdf$$yVersión publicada
000089616 8564_ $$s423639$$uhttps://zaguan.unizar.es/record/89616/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
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000089616 951__ $$a2021-09-02-09:01:49
000089616 980__ $$aARTICLE