Update on TB vaccine pipeline

Martin, Carlos (Universidad de Zaragoza) ; Aguilo, Nacho (Universidad de Zaragoza) ; Marinova, Dessislava (Universidad de Zaragoza) ; Gonzalo-Asensio, Jesús (Universidad de Zaragoza)

Resumen: In addition to antibiotics, vaccination is considered among the most efficacious methods in the control and the potential eradication of infectious diseases. New safe and effective vaccines against tuberculosis (TB) could be a very important tool and are called to play a significant role in the fight against TB resistant to antimicrobials. Despite the extended use of the current TB vaccine Bacillus Calmette-Guerin (BCG), TB continues to be transmitted actively and continues to be one of the 10 most important causes of death in the world. In the last 20 years, different TB vaccines have entered clinical trials. In this paper, we review the current use of BCG and the diversity of vaccines in clinical trials and their possible indications. New TB vaccines capable of protecting against respiratory forms of the disease caused by sensitive or resistant Mycobacterium tuberculosis strains would be extremely useful tools helping to prevent the emergence of multi-drug resistance.

Idioma: Inglés

DOI: 10.3390/app10072632

Año: 2020

Publicado en: APPLIED SCIENCES-BASEL 10, 7 (2020), 2632 [15 pp.]
ISSN: 2076-3417

Factor impacto JCR: 2.679 (2020)

Categ. JCR: PHYSICS, APPLIED rank: 73 / 160 = 0.456 (2020) - Q2 - T2
Categ. JCR: ENGINEERING, MULTIDISCIPLINARY rank: 38 / 91 = 0.418 (2020) - Q2 - T2
Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 101 / 178 = 0.567 (2020) - Q3 - T2
Categ. JCR: MATERIALS SCIENCE, MULTIDISCIPLINARY rank: 201 / 333 = 0.604 (2020) - Q3 - T2

Factor impacto SCIMAGO: 0.435 - Computer Science Applications (Q2) - Engineering (miscellaneous) (Q2) - Process Chemistry and Technology (Q2) - Instrumentation (Q2) - Materials Science (miscellaneous) (Q2) - Fluid Flow and Transfer Processes (Q2)

Financiación: info:eu-repo/grantAgreement/EUR/EDCTP/RIA2016V-1637
Financiación: info:eu-repo/grantAgreement/ES/MICINN/RTI2018-097625-B-100

Tipo y forma: Revisión (Versión definitiva)

Área (Departamento): Área Microbiología (Dpto. Microb.Ped.Radio.Sal.Pú.)
Área (Departamento): Proy. investigación HQA (Dpto. Microb.Ped.Radio.Sal.Pú.)