000089697 001__ 89697 000089697 005__ 20210902121714.0 000089697 0247_ $$2doi$$a10.3390/app10072632 000089697 0248_ $$2sideral$$a117832 000089697 037__ $$aART-2020-117832 000089697 041__ $$aeng 000089697 100__ $$0(orcid)0000-0003-2993-5478$$aMartin, Carlos$$uUniversidad de Zaragoza 000089697 245__ $$aUpdate on TB vaccine pipeline 000089697 260__ $$c2020 000089697 5060_ $$aAccess copy available to the general public$$fUnrestricted 000089697 5203_ $$aIn addition to antibiotics, vaccination is considered among the most efficacious methods in the control and the potential eradication of infectious diseases. New safe and effective vaccines against tuberculosis (TB) could be a very important tool and are called to play a significant role in the fight against TB resistant to antimicrobials. Despite the extended use of the current TB vaccine Bacillus Calmette-Guerin (BCG), TB continues to be transmitted actively and continues to be one of the 10 most important causes of death in the world. In the last 20 years, different TB vaccines have entered clinical trials. In this paper, we review the current use of BCG and the diversity of vaccines in clinical trials and their possible indications. New TB vaccines capable of protecting against respiratory forms of the disease caused by sensitive or resistant Mycobacterium tuberculosis strains would be extremely useful tools helping to prevent the emergence of multi-drug resistance. 000089697 536__ $$9info:eu-repo/grantAgreement/EUR/EDCTP/RIA2016V-1637$$9info:eu-repo/grantAgreement/ES/MICINN/RTI2018-097625-B-100 000089697 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000089697 590__ $$a2.679$$b2020 000089697 591__ $$aPHYSICS, APPLIED$$b73 / 160 = 0.456$$c2020$$dQ2$$eT2 000089697 591__ $$aENGINEERING, MULTIDISCIPLINARY$$b38 / 91 = 0.418$$c2020$$dQ2$$eT2 000089697 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b101 / 178 = 0.567$$c2020$$dQ3$$eT2 000089697 591__ $$aMATERIALS SCIENCE, MULTIDISCIPLINARY$$b201 / 333 = 0.604$$c2020$$dQ3$$eT2 000089697 592__ $$a0.435$$b2020 000089697 593__ $$aComputer Science Applications$$c2020$$dQ2 000089697 593__ $$aEngineering (miscellaneous)$$c2020$$dQ2 000089697 593__ $$aProcess Chemistry and Technology$$c2020$$dQ2 000089697 593__ $$aInstrumentation$$c2020$$dQ2 000089697 593__ $$aMaterials Science (miscellaneous)$$c2020$$dQ2 000089697 593__ $$aFluid Flow and Transfer Processes$$c2020$$dQ2 000089697 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/publishedVersion 000089697 700__ $$0(orcid)0000-0001-7897-9173$$aAguilo, Nacho$$uUniversidad de Zaragoza 000089697 700__ $$0(orcid)0000-0001-8644-120X$$aMarinova, Dessislava$$uUniversidad de Zaragoza 000089697 700__ $$0(orcid)0000-0001-8841-6593$$aGonzalo-Asensio, Jesús$$uUniversidad de Zaragoza 000089697 7102_ $$11011$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Microbiología 000089697 7102_ $$11011$$2X$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cProy. investigación HQA 000089697 773__ $$g10, 7 (2020), 2632 [15 pp.]$$pAppl. sci.$$tAPPLIED SCIENCES-BASEL$$x2076-3417 000089697 8564_ $$s1410149$$uhttps://zaguan.unizar.es/record/89697/files/texto_completo.pdf$$yVersión publicada 000089697 8564_ $$s529063$$uhttps://zaguan.unizar.es/record/89697/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000089697 909CO $$ooai:zaguan.unizar.es:89697$$particulos$$pdriver 000089697 951__ $$a2021-09-02-09:22:48 000089697 980__ $$aARTICLE