000089709 001__ 89709
000089709 005__ 20230914083302.0
000089709 0247_ $$2doi$$a10.3390/antibiotics9040175
000089709 0248_ $$2sideral$$a117846
000089709 037__ $$aART-2020-117846
000089709 041__ $$aeng
000089709 100__ $$0(orcid)0000-0003-3850-9833$$aSerrano, María Jesús
000089709 245__ $$aIs blood a good indicator for detecting antimicrobials in meat? Evidence for the development of in vivo surveillance methods
000089709 260__ $$c2020
000089709 5060_ $$aAccess copy available to the general public$$fUnrestricted
000089709 5203_ $$aThe introduction of antimicrobial residues in the food chain has a significant impact on human health. An innovative solution to avoid their presence in meat is the adaptation of current control methods for use with in vivo matrixes. Thus, the aim was to obtain paired blood and muscle samples from pigs treated with some of the main antimicrobials currently used in veterinary medicine (oxytetracycline, sulfamethoxypyridazine, enrofloxacin, amoxicillin), and to compare their rate of depletion in both matrixes. Antimicrobial concentrations in paired samples of blood and muscle were determined by liquid chromatography with tandem mass spectrometry (LC- MS/MS) or high performance liquid chromatography with fluorescence detection (HPLC-FLD). A comparison between values obtained in muscle and blood showed a similar distribution in both matrixes for oxytetracycline; for sulfamethoxypyridazine, a similar decrease rate but a concentration three times higher in blood compared to muscle was found; for enrofloxacin, we found significant differences in the rate of depletion, with similar antimicrobial concentrations in both matrixes with values close to the maximum residue limit (MRL) and higher amounts in muscle for values that lay considerably over the MRL. Conversely, amoxicillin depletion was so rapid that its appearance in carcasses does not seem to pose a risk. Therefore, blood would be a feasible matrix for the development of new in vivo tests.
000089709 536__ $$9info:eu-repo/grantAgreement/EUR/INTERREG-V-A-POCTEFA/TESTACOS-EFA152/16$$9info:eu-repo/grantAgreement/EUR/INTERREG-V-A-POCTEFA-2014-2020
000089709 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000089709 590__ $$a4.639$$b2020
000089709 591__ $$aPHARMACOLOGY & PHARMACY$$b76 / 275 = 0.276$$c2020$$dQ2$$eT1
000089709 591__ $$aINFECTIOUS DISEASES$$b26 / 92 = 0.283$$c2020$$dQ2$$eT1
000089709 592__ $$a0.96$$b2020
000089709 593__ $$aBiochemistry$$c2020$$dQ1
000089709 593__ $$aInfectious Diseases$$c2020$$dQ1
000089709 593__ $$aPharmacology, Toxicology and Pharmaceutics (miscellaneous)$$c2020$$dQ1
000089709 593__ $$aMicrobiology (medical)$$c2020$$dQ1
000089709 593__ $$aPharmacology (medical)$$c2020$$dQ1
000089709 593__ $$aMicrobiology$$c2020$$dQ1
000089709 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000089709 700__ $$0(orcid)0000-0001-9907-2941$$aMitjana, Olga$$uUniversidad de Zaragoza
000089709 700__ $$0(orcid)0000-0001-6178-9891$$aBonastre, Cristina$$uUniversidad de Zaragoza
000089709 700__ $$0(orcid)0000-0003-0296-1617$$aLaborda, Alicia$$uUniversidad de Zaragoza
000089709 700__ $$0(orcid)0000-0001-6964-7011$$aFalceto, María Victoria$$uUniversidad de Zaragoza
000089709 700__ $$0(orcid)0000-0002-7629-8101$$aGarcía-Gonzalo, Diego$$uUniversidad de Zaragoza
000089709 700__ $$aAbilleira, Eunate
000089709 700__ $$aElorduy, Janire
000089709 700__ $$aBousquet-Melou, Alain
000089709 700__ $$aMata, Luis
000089709 700__ $$0(orcid)0000-0002-1902-0648$$aCondón, Santiago$$uUniversidad de Zaragoza
000089709 700__ $$0(orcid)0000-0002-0238-6328$$aPagán, Rafael$$uUniversidad de Zaragoza
000089709 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal
000089709 7102_ $$12008$$2780$$aUniversidad de Zaragoza$$bDpto. Produc.Animal Cienc.Ali.$$cÁrea Tecnología de Alimentos
000089709 773__ $$g9, 4 (2020), 175 [16 pp.]$$pAntibiotics$$tAntibiotics$$x2079-6382
000089709 8564_ $$s625503$$uhttps://zaguan.unizar.es/record/89709/files/texto_completo.pdf$$yVersión publicada
000089709 8564_ $$s495508$$uhttps://zaguan.unizar.es/record/89709/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000089709 909CO $$ooai:zaguan.unizar.es:89709$$particulos$$pdriver
000089709 951__ $$a2023-09-13-10:54:05
000089709 980__ $$aARTICLE