Is blood a good indicator for detecting antimicrobials in meat? Evidence for the development of in vivo surveillance methods
Resumen: The introduction of antimicrobial residues in the food chain has a significant impact on human health. An innovative solution to avoid their presence in meat is the adaptation of current control methods for use with in vivo matrixes. Thus, the aim was to obtain paired blood and muscle samples from pigs treated with some of the main antimicrobials currently used in veterinary medicine (oxytetracycline, sulfamethoxypyridazine, enrofloxacin, amoxicillin), and to compare their rate of depletion in both matrixes. Antimicrobial concentrations in paired samples of blood and muscle were determined by liquid chromatography with tandem mass spectrometry (LC- MS/MS) or high performance liquid chromatography with fluorescence detection (HPLC-FLD). A comparison between values obtained in muscle and blood showed a similar distribution in both matrixes for oxytetracycline; for sulfamethoxypyridazine, a similar decrease rate but a concentration three times higher in blood compared to muscle was found; for enrofloxacin, we found significant differences in the rate of depletion, with similar antimicrobial concentrations in both matrixes with values close to the maximum residue limit (MRL) and higher amounts in muscle for values that lay considerably over the MRL. Conversely, amoxicillin depletion was so rapid that its appearance in carcasses does not seem to pose a risk. Therefore, blood would be a feasible matrix for the development of new in vivo tests.
Idioma: Inglés
DOI: 10.3390/antibiotics9040175
Año: 2020
Publicado en: Antibiotics 9, 4 (2020), 175 [16 pp.]
ISSN: 2079-6382

Factor impacto JCR: 4.639 (2020)
Categ. JCR: PHARMACOLOGY & PHARMACY rank: 76 / 275 = 0.276 (2020) - Q2 - T1
Categ. JCR: INFECTIOUS DISEASES rank: 26 / 92 = 0.283 (2020) - Q2 - T1

Factor impacto SCIMAGO: 0.96 - Biochemistry (Q1) - Infectious Diseases (Q1) - Pharmacology, Toxicology and Pharmaceutics (miscellaneous) (Q1) - Microbiology (medical) (Q1) - Pharmacology (medical) (Q1) - Microbiology (Q1)

Financiación: info:eu-repo/grantAgreement/EUR/INTERREG-V-A-POCTEFA/TESTACOS-EFA152/16
Financiación: info:eu-repo/grantAgreement/EUR/INTERREG-V-A-POCTEFA-2014-2020
Tipo y forma: Article (Published version)
Área (Departamento): Área Medicina y Cirugía Animal (Dpto. Patología Animal)
Área (Departamento): Área Tecnología de Alimentos (Dpto. Produc.Animal Cienc.Ali.)

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