GaN-Based versatile waveform generator for biomedical applications of electroporation

Sarnago, Héctor (Universidad de Zaragoza) ; Burdio, José M. (Universidad de Zaragoza) ; Garcia-Sanchez, Tomás ; Mir, Lluis M. ; Alvarez-Gariburo, Ignacio (Universidad de Zaragoza) ; Lucia, Óscar (Universidad de Zaragoza)

Resumen: Biomedical applications often require high-performance power supplies for diagnosis and treatment systems. In particular, modern electroporation techniques for cancer treatment require high-voltage generators with versatile waveform generation. In this context, sinusoidal waveform generation has been recently identified as beneficial for electrochemotherapy cancer treatments. This paper proposes the design of a high-voltage high-frequency arbitrary waveform generator taking advantage of Gallium Nitride (GaN) devices. The proposed converter has been designed and implemented, achieving a 1-MHz 2000-V output voltage. It has been electrically tested and applied to electrochemotherapy treatments in mice, demonstrating the feasibility of this proposal.

Idioma: Inglés

DOI: 10.1109/ACCESS.2020.2996426

Año: 2020

Publicado en: IEEE Access 8 (2020), 97196-97203
ISSN: 2169-3536

Factor impacto JCR: 3.367 (2020)

Categ. JCR: COMPUTER SCIENCE, INFORMATION SYSTEMS rank: 65 / 162 = 0.401 (2020) - Q2 - T2
Categ. JCR: TELECOMMUNICATIONS rank: 36 / 91 = 0.396 (2020) - Q2 - T2
Categ. JCR: ENGINEERING, ELECTRICAL & ELECTRONIC rank: 94 / 273 = 0.344 (2020) - Q2 - T2

Factor impacto SCIMAGO: 0.586 - Computer Science (miscellaneous) (Q1) - Materials Science (miscellaneous) (Q1) - Engineering (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA/LMP106-18
Financiación: info:eu-repo/grantAgreement/ES/MINECO/TEC2016-78358-R

Tipo y forma: Article (Published version)

Área (Departamento): Área Tecnología Electrónica (Dpto. Ingeniería Electrón.Com.)