000095361 001__ 95361
000095361 005__ 20210902121829.0
000095361 0247_ $$2doi$$a10.3390/ma13132925
000095361 0248_ $$2sideral$$a119157
000095361 037__ $$aART-2020-119157
000095361 041__ $$aeng
000095361 100__ $$0(orcid)0000-0002-1505-498X$$aYus, Cristina$$uUniversidad de Zaragoza
000095361 245__ $$aMicroflow nanoprecipitation of positively charged gastroresistant polymer nanoparticles of Eudragit® RS100: A study of fluid dynamics and chemical parameters
000095361 260__ $$c2020
000095361 5060_ $$aAccess copy available to the general public$$fUnrestricted
000095361 5203_ $$aThe objective of the present work was to produce gastroresistant Eudragit® RS100 nanoparticles by a reproducible synthesis approach that ensured mono-disperse nanoparticles under the size of 100 nm. Batch and micromixing nanoprecipitation approaches were selected to produce the demanded nanoparticles, identifying the critical parameters affecting the synthesis process. To shed some light on the formulation of the targeted nanoparticles, the effects of particle size and homogeneity of fluid dynamics, and physicochemical parameters such as polymer concentration, type of solvent, ratio of solvent to antisolvent, and total flow rate were studied. The physicochemical characteristics of resulting nanoparticles were studied applying dynamic light scattering (DLS) particle size analysis and electron microscopy imaging. Nanoparticles produced using a micromixer demonstrated a narrower and more homogenous distribution than the ones obtained under similar conditions in conventional batch reactors. Besides, fluid dynamics ensured that the best mixing conditions were achieved at the highest flow rate. It was concluded that nucleation and growth events must also be considered to avoid uncontrolled nanoparticle growth and evolution at the collection vial. Further, rifampicin-encapsulated nanoparticles were prepared using both approaches, demonstrating that the micromixing-assisted approach provided an excellent control of the particle size and polydispersity index. Not only the micromixing-assisted nanoprecipitation promoted a remarkable control in the nanoparticle formulation, but also it enhanced drug encapsulation efficiency and loading, as well as productivity. To the best of our knowledge, this was the very first time that drug-loaded Eudragit® RS100 nanoparticles (NPs) were produced in a continuous fashion under 100 nm (16.5 ± 4.3 nm) using microreactor technology. Furthermore, we performed a detailed analysis of the influence of various fluid dynamics and physicochemical parameters on the size and uniformity of the resulting nanoparticles. According to these findings, the proposed methodology can be a useful approach to synthesize a myriad of nanoparticles of alternative polymers.
000095361 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/RTI2018-099019-A-I00$$9info:eu-repo/grantAgreement/ES/MINECO/CTQ2017-84473-R
000095361 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000095361 590__ $$a3.623$$b2020
000095361 591__ $$aMETALLURGY & METALLURGICAL ENGINEERING$$b17 / 80 = 0.213$$c2020$$dQ1$$eT1
000095361 591__ $$aMATERIALS SCIENCE, MULTIDISCIPLINARY$$b152 / 333 = 0.456$$c2020$$dQ2$$eT2
000095361 591__ $$aPHYSICS, CONDENSED MATTER$$b27 / 69 = 0.391$$c2020$$dQ2$$eT2
000095361 591__ $$aPHYSICS, APPLIED$$b51 / 160 = 0.319$$c2020$$dQ2$$eT1
000095361 591__ $$aCHEMISTRY, PHYSICAL$$b79 / 162 = 0.488$$c2020$$dQ2$$eT2
000095361 592__ $$a0.682$$b2020
000095361 593__ $$aMaterials Science (miscellaneous)$$c2020$$dQ2
000095361 593__ $$aCondensed Matter Physics$$c2020$$dQ2
000095361 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000095361 700__ $$0(orcid)0000-0003-3165-0156$$aArruebo, Manuel$$uUniversidad de Zaragoza
000095361 700__ $$0(orcid)0000-0002-2966-9088$$aIrusta, Silvia$$uUniversidad de Zaragoza
000095361 700__ $$0(orcid)0000-0002-6873-5244$$aSebastián, Víctor$$uUniversidad de Zaragoza
000095361 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000095361 7102_ $$15005$$2790$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Tecnologi. Medio Ambiente
000095361 773__ $$g13, 13 (2020), 2925 [23 pp.]$$pMATERIALS$$tMATERIALS$$x1996-1944
000095361 8564_ $$s3456807$$uhttps://zaguan.unizar.es/record/95361/files/texto_completo.pdf$$yVersión publicada
000095361 8564_ $$s506946$$uhttps://zaguan.unizar.es/record/95361/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
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000095361 951__ $$a2021-09-02-10:14:09
000095361 980__ $$aARTICLE