Antioxidants and oxidative stress in children: Influence of puberty and metabolically unhealthy status

Rupérez, Azahara I. (Universidad de Zaragoza) ; Mesa, María D. ; Anguita-Ruiz, Augusto ; González-Gil, Esther M. ; Vázquez-Cobela, Rocío ; Moreno, Luis A. (Universidad de Zaragoza) ; Gil, Ángel ; Gil-Campos, Mercedes ; Leis, Rosaura ; Bueno, Gloria (Universidad de Zaragoza) ; Aguilera, Concepción M.

Resumen: Oxidative stress could help explain the relationship between childhood obesity and a metabolically unhealthy (MU) status. Moreover, puberty could also influence this relationship, since it entails physiological cardiometabolic changes. We aimed to evaluate plasma antioxidants and oxidative stress biomarkers in MU and metabolically healthy (MH) prepubertal and pubertal children and their associations with pro-inflammatory and endothelial damage biomarkers, taking puberty into account. A total of 1444 Spanish children aged 3–17 years (48.9% males, 66% prepubertal, 47.1% with obesity) were recruited. Blood pressure, anthropometric and biochemical parameters were measured, and children were categorized as having a MU or MH status according to risk factors. Retinol, carotenes, tocopherols, total antioxidant capacity (TAC), oxidized low-density lipoprotein and selected pro-inflammatory and endothelial damage biomarkers were analyzed. General linear models adjusted for age, sex, recruitment center and body mass index, partial correlations and stepwise linear regressions were performed. Lower carotenes and tocopherols levels were found in MU than in MH children. Plasma TAC was lower in prepubertal and higher in pubertal children with obesity compared to normal-weight children. Antioxidants and oxidative stress biomarkers showed novel associations with several pro-inflammatory and endothelial damage biomarkers, with pubertal differences, supporting the importance of considering both the antioxidant and oxidative stress status and puberty in the prevention of metabolic diseases in childhood.

Idioma: Inglés

DOI: 10.3390/antiox9070618

Año: 2020

Publicado en: Antioxidants 9, 7 (2020), 618 [19 pp.]
ISSN: 2076-3921

Factor impacto JCR: 6.312 (2020)

Categ. JCR: BIOCHEMISTRY & MOLECULAR BIOLOGY rank: 60 / 297 = 0.202 (2020) - Q1 - T1
Categ. JCR: FOOD SCIENCE & TECHNOLOGY rank: 11 / 144 = 0.076 (2020) - Q1 - T1
Categ. JCR: CHEMISTRY, MEDICINAL rank: 6 / 63 = 0.095 (2020) - Q1 - T1

Factor impacto SCIMAGO: 1.066 - Biochemistry (Q2) - Cell Biology (Q2) - Physiology (Q2) - Molecular Biology (Q2) - Clinical Biochemistry (Q2)

Financiación: info:eu-repo/grantAgreement/ES/CIBERObn/CB15-00043
Financiación: info:eu-repo/grantAgreement/ES/CIBERObn/CB15-00131
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI051968
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI11-01425
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI11-02042
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI11-02059
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI16-00871
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI16-012
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI16-01301
Financiación: info:eu-repo/grantAgreement/ES/Spanish Ministry of Health/CIBERobn CB12-03-30038

Tipo y forma: Article (Published version)

Área (Departamento): Área Enfermería (Dpto. Fisiatría y Enfermería)
Área (Departamento): Área Pediatría (Dpto. Microb.Ped.Radio.Sal.Pú.)