Cancer-derived exosomes loaded with ultrathin palladium nanosheets for targeted bioorthogonal catalysis

Sancho-Albero, María (Universidad de Zaragoza) ; Rubio-Ruiz, Belén ; Pérez-López, Ana M. ; Sebastián, Víctor (Universidad de Zaragoza) ; Martín-Duque, Pilar ; Arruebo, Manuel (Universidad de Zaragoza) ; Santamaría, Jesús (Universidad de Zaragoza) ; Unciti-Broceta, Asier

Resumen: The transformational impact of bioorthogonal chemistries has inspired new strategies for the in vivo synthesis of bioactive agents through non-natural means. Among these, Pd catalysts have played a prominent role in the growing subfield of bioorthogonal catalysis by producing xenobiotics and uncaging biomolecules in living systems. However, delivering catalysts selectively to specific cell types still lags behind catalyst development. Here, we have developed a bioartificial device comprising cancer-derived exosomes that are loaded with Pd catalysts by a method that enables the controlled assembly of Pd nanosheets directly inside the vesicles. This hybrid system mediates Pd-triggered dealkylation reactions in vitro and inside cells, and displays preferential tropism for their progenitor cells. The use of Trojan exosomes to deliver abiotic catalysts into designated cancer cells creates the opportunity for a new targeted therapy modality; that is, exosome-directed catalyst prodrug therapy, whose first steps are presented herein with the cell-specific release of the anticancer drug panobinostat.

Idioma: Inglés

DOI: 10.1038/s41929-019-0333-4

Año: 2019

Publicado en: Nature Catalysis 2, 10 (2019), 864–872
ISSN: 2520-1158

Factor impacto JCR: 30.471 (2019)

Categ. JCR: CHEMISTRY, PHYSICAL rank: 2 / 159 = 0.013 (2019) - Q1 - T1

Factor impacto SCIMAGO: 11.104 - Biochemistry (Q1) - Process Chemistry and Technology (Q1) - Catalysis (Q1) - Bioengineering (Q1)

Financiación: info:eu-repo/grantAgreement/EC/FP7/614715/EU/A Photo-triggered On-demand Drug Delivery System for Chronic Pain/NANOHEDONISM
Financiación: info:eu-repo/grantAgreement/EC/H2020/658833/EU/Development of Palladium-Labile Prodrugs for Bioorthogonally-Activated Chemotherapy/ChemoBOOM
Financiación: info:eu-repo/grantAgreement/EC/H2020/742684/EU/Catalytic Dual-Function Devices Against Cancer/CADENCE

Tipo y forma: Artículo (PostPrint)

Área (Departamento): Área Ingeniería Química (Dpto. Ing.Quím.Tecnol.Med.Amb.)