Clinical Outcome in Human T-Lymphotropic Virus Type 2 Carriers Following Organ Transplantation
Benito, R. (Universidad de Zaragoza) ; Gil, J. ; Sahagún, J. (Universidad de Zaragoza) ; Soriano, V.
Resumen: Background: Frequent and rapid development of myelopathy has been reported in individuals with human T-lymphotropic virus type 1 (HTLV-1) infection following solid organ transplantation. There is no information regarding HTLV-2, a closely related virus that often infects injection drug users.
Methods: This study includes a retrospective analysis of all consecutive organ transplants performed during the last 2 decades at a large reference transplantation unit in Spain. All participants were tested for anti-HTLV antibodies.
Results: A total of 2019 individuals were tested for HTLV during the study period, including 663 potential donors and 1356 recipient candidates. Twelve (0.59%) were reactive on initial HTLV serologic screening, but only 6 (all recipients) were confirmed as positive, all for HTLV-2. Two recipients underwent liver transplantation and have remained asymptomatic despite being on tacrolimus for 4 and 8 years, respectively. Likewise, the remaining 4 HTLV-2 carriers have not developed clinical complications potentially associated with HTLV-2.
Conclusions: Unlike HTLV-1 infection, HTLV-2 infection in the transplantation setting does not seem to be associated with rapid development of neurologic complications, Given the cross-seroreactivity between HTLV-1 and HTLV-2, discriminatory rapid tests are urgently needed and would reduce unnecessary organ discharge.
Idioma: Inglés
DOI: 10.1016/j.transproceed.2020.08.029
Año: 2021
Publicado en: Transplantation Proceedings 53, 2 (2021), 743-745
ISSN: 0041-1345
Factor impacto JCR: 1.014 (2021)
Categ. JCR: IMMUNOLOGY rank: 159 / 163 = 0.975 (2021) - Q4 - T3
Categ. JCR: TRANSPLANTATION rank: 24 / 26 = 0.923 (2021) - Q4 - T3
Categ. JCR: SURGERY rank: 191 / 214 = 0.893 (2021) - Q4 - T3
Factor impacto CITESCORE: 1.7 - Medicine (Q3)
Factor impacto SCIMAGO: 0.286 - Transplantation (Q3) - Surgery (Q3)
Tipo y forma: Article (Published version)
Área (Departamento): Área Microbiología (Dpto. Microb.Ped.Radio.Sal.Pú.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you may not distribute the modified material.
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Methods: This study includes a retrospective analysis of all consecutive organ transplants performed during the last 2 decades at a large reference transplantation unit in Spain. All participants were tested for anti-HTLV antibodies.
Results: A total of 2019 individuals were tested for HTLV during the study period, including 663 potential donors and 1356 recipient candidates. Twelve (0.59%) were reactive on initial HTLV serologic screening, but only 6 (all recipients) were confirmed as positive, all for HTLV-2. Two recipients underwent liver transplantation and have remained asymptomatic despite being on tacrolimus for 4 and 8 years, respectively. Likewise, the remaining 4 HTLV-2 carriers have not developed clinical complications potentially associated with HTLV-2.
Conclusions: Unlike HTLV-1 infection, HTLV-2 infection in the transplantation setting does not seem to be associated with rapid development of neurologic complications, Given the cross-seroreactivity between HTLV-1 and HTLV-2, discriminatory rapid tests are urgently needed and would reduce unnecessary organ discharge.
Idioma: Inglés
DOI: 10.1016/j.transproceed.2020.08.029
Año: 2021
Publicado en: Transplantation Proceedings 53, 2 (2021), 743-745
ISSN: 0041-1345
Factor impacto JCR: 1.014 (2021)
Categ. JCR: IMMUNOLOGY rank: 159 / 163 = 0.975 (2021) - Q4 - T3
Categ. JCR: TRANSPLANTATION rank: 24 / 26 = 0.923 (2021) - Q4 - T3
Categ. JCR: SURGERY rank: 191 / 214 = 0.893 (2021) - Q4 - T3
Factor impacto CITESCORE: 1.7 - Medicine (Q3)
Factor impacto SCIMAGO: 0.286 - Transplantation (Q3) - Surgery (Q3)
Tipo y forma: Article (Published version)
Área (Departamento): Área Microbiología (Dpto. Microb.Ped.Radio.Sal.Pú.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you may not distribute the modified material. Exportado de SIDERAL (2023-05-18-13:20:56)
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Record created 2020-10-20, last modified 2023-05-19